Diferensiasi Asma Atopik dengan Nonatopik pada Pasien Rawat Jalan di Klinik Paru-Asma

• Main Authors: Prayudi Santoso, Zul Dahlan
• Format: Article
• Language: English
• Published: Universitas Padjajaran 2013-06-01
• Series: Majalah Kedokteran Bandung
• Subjects: Atopic asthma; clinical characteristics; IgE; non-atopic asthma
• Online Access: http://journal.fk.unpad.ac.id/index.php/mkb/article/view/112
• ISSN: 0126-074X; 2338-6223

There is a difficulty in asthma management regarding to unclear mechanism of asthma, and a variety of asthma phenotypes that individually require individual therapy and approach. The asthmatic phenotype atopic and nonatopic was clinically difficult to distinguish. The study was analytical descriptive with cross-sectional design. The study aim was to explore the differences of atopic and non-atopic asthmatic characteristics. The study subjects were newly asthmatic patients who were out-patients of An-Nur Lung-Asthmatic Clinic, Bandung, in 2007–2008. In patients examined total IgE, spirometry and skin prick test. There were 198 asthmatic patients comprising 149 (75.3%) atopic and 40 (24.7%) non-atopic asthma. The median of the non-atopic age was 39 years, while the atopic was 34 years (p=0.039). There was a significant difference between atopic (68.5%) and non-atopic (44.9%) in complaint of short breath (p=0.003), but non significant in spirometric examination. The history of atopy were present in atopic asthma group (p=0.011), with significance in rhinitis (81.2 vs 61.2 OR=2.7) and urticaria (14.8 vs 4.1 OR=4.0). Non-atopic asthma was not more severe that atopic asthma was known from examination of forced expiratory volume first second (FEV1). Rhinitis patient, having urticaria, have greater risk for atopic asthma. There were no difference in skin prick test results between both groups. The clinical symptoms of atopic group were in line with the positivenes results of IgE examination. Clinical condition of rhinitis and urticaria direct to the diagnosed towards atopic asthma compared than other clinical features or spirometric result.