The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats

• Main Authors: Toraj Mohammad zamani, Ahmadreza Movahedi, Elahe Arab ameri
• Format: Article
• Language: fas
• Published: Ilam University of Medical Sciences 2019-03-01
• Series: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
• Subjects: Compulsory sports; Prenatal stress; Substantia nigra tissue; Parkinson’s disease
• Online Access: http://sjimu.medilam.ac.ir/browse.php?a_code=A-10-4698-2&slc_lang=en&sid=1

Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress. Exercising activity is a good way to prevent the disease. The aim of this study was to investigate the effect of mandatory exercise on Substantia nigra tissue in Perinatal Parkinson's rats.   Materials & Methods: A Laboratory research method was used. 48 Wistar male rats, half of them under prenatal stress And followed up on compulsory sports activities. Were divided into 8 groups of 6, with stress (control, sham, Parkinson, Parkinson + compulsory exercise) and without stress (control, sham, Parkinson, Parkinson + compulsory exercise). the animals received Stereotaxic Surgery after 8 weeks, Three weeks later, Parkinson's symptoms were evaluated using Apo morphine rotation test and Wire grasping. The number of substantia nigra neurons in the brain is counted using a microscope; Data were analyzed using One-Way ANOVA and Tukey's Post Test. Ethics code: IR.IAU.SRB.REC.1396   Findings: In groups with and without stress, the number of substantia nigra neurons compulsory sports group was different from that of the control group and this difference was statistically significant (P=0.0000). The average number of substantia nigra neurons compulsory sports group in both groups with and without stress difference was low, but statistically significant (P=0.014).   Discussion & conclusions: The results refer to the effects of compulsive exercise on the better protection of Substantia nigra neurons and suggests that exercise can be effective as a beneficial factor in reducing the degeneration of dopaminergic neurons in Parkinson's disease. Prenatal stress also reduces the beneficial effects of exercise.