Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial
Aim. Efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (PONV) in children undergoing elective strabismus surgery. Methods. A total of 136 children (1–15 years) were included. Children received either granisetron...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2016-01-01
|
Series: | Anesthesiology Research and Practice |
Online Access: | http://dx.doi.org/10.1155/2016/4281719 |
id |
doaj-0509535faf5448519c4210c8a92246cd |
---|---|
record_format |
Article |
spelling |
doaj-0509535faf5448519c4210c8a92246cd2020-11-25T01:56:38ZengHindawi LimitedAnesthesiology Research and Practice1687-69621687-69702016-01-01201610.1155/2016/42817194281719Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind TrialRenu Sinha0Dilip Shende1Souvik Maitra2Neeraj Kumar3Bikash Ranjan Ray4Virender Kumar Mohan5Room Number 376, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, IndiaRoom Number 374, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, IndiaRoom Number 5011, Department of Anaesthesiology, AIIMS, New Delhi, IndiaRoom Number 5011, Department of Anaesthesiology, AIIMS, New Delhi, IndiaRoom Number 5011, Department of Anaesthesiology, AIIMS, New Delhi, IndiaRoom Number 5007, Department of Anaesthesiology, AIIMS, New Delhi, IndiaAim. Efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (PONV) in children undergoing elective strabismus surgery. Methods. A total of 136 children (1–15 years) were included. Children received either granisetron (40 mcg/kg) [group G] or combination of granisetron (40 mcg/kg) and dexamethasone (150 mcg/kg) [group GD]. Intraoperative fentanyl requirement and incidence and severity of oculocardiac reflex were assessed. PONV severity was assessed for first 24 hours and if score was >2, it was treated with metoclopramide. Postoperative analgesia was administered with intravenous fentanyl and ibuprofen. Results. The demographic profile, muscles operated, and fentanyl requirement were comparable. Complete response to PONV in first 24 hours was observed in 75% (51/68) of children in group G and 76.9% (50/65) of children in group GD, which was comparable statistically (p=0.96, Fisher exact test; OR 1.11, 95% CI 0.50, 2.46). Incidence of PONV between 0 and 24 hours was comparable. One child in group G required rescue antiemetic in first 24 hours and none of the children had severe PONV in group GD. There was no significant difference in incidence or severity of oculocardiac reflex. Conclusion. Dexamethasone did not increase efficacy of granisetron for prevention of PONV in elective pediatric strabismus surgery. Registration number of clinical trial was CTRI/2009/091/001000.http://dx.doi.org/10.1155/2016/4281719 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Renu Sinha Dilip Shende Souvik Maitra Neeraj Kumar Bikash Ranjan Ray Virender Kumar Mohan |
spellingShingle |
Renu Sinha Dilip Shende Souvik Maitra Neeraj Kumar Bikash Ranjan Ray Virender Kumar Mohan Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial Anesthesiology Research and Practice |
author_facet |
Renu Sinha Dilip Shende Souvik Maitra Neeraj Kumar Bikash Ranjan Ray Virender Kumar Mohan |
author_sort |
Renu Sinha |
title |
Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial |
title_short |
Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial |
title_full |
Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial |
title_fullStr |
Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial |
title_full_unstemmed |
Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial |
title_sort |
granisetron versus granisetron-dexamethasone for prevention of postoperative nausea and vomiting in pediatric strabismus surgery: a randomized double-blind trial |
publisher |
Hindawi Limited |
series |
Anesthesiology Research and Practice |
issn |
1687-6962 1687-6970 |
publishDate |
2016-01-01 |
description |
Aim. Efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (PONV) in children undergoing elective strabismus surgery. Methods. A total of 136 children (1–15 years) were included. Children received either granisetron (40 mcg/kg) [group G] or combination of granisetron (40 mcg/kg) and dexamethasone (150 mcg/kg) [group GD]. Intraoperative fentanyl requirement and incidence and severity of oculocardiac reflex were assessed. PONV severity was assessed for first 24 hours and if score was >2, it was treated with metoclopramide. Postoperative analgesia was administered with intravenous fentanyl and ibuprofen. Results. The demographic profile, muscles operated, and fentanyl requirement were comparable. Complete response to PONV in first 24 hours was observed in 75% (51/68) of children in group G and 76.9% (50/65) of children in group GD, which was comparable statistically (p=0.96, Fisher exact test; OR 1.11, 95% CI 0.50, 2.46). Incidence of PONV between 0 and 24 hours was comparable. One child in group G required rescue antiemetic in first 24 hours and none of the children had severe PONV in group GD. There was no significant difference in incidence or severity of oculocardiac reflex. Conclusion. Dexamethasone did not increase efficacy of granisetron for prevention of PONV in elective pediatric strabismus surgery. Registration number of clinical trial was CTRI/2009/091/001000. |
url |
http://dx.doi.org/10.1155/2016/4281719 |
work_keys_str_mv |
AT renusinha granisetronversusgranisetrondexamethasoneforpreventionofpostoperativenauseaandvomitinginpediatricstrabismussurgeryarandomizeddoubleblindtrial AT dilipshende granisetronversusgranisetrondexamethasoneforpreventionofpostoperativenauseaandvomitinginpediatricstrabismussurgeryarandomizeddoubleblindtrial AT souvikmaitra granisetronversusgranisetrondexamethasoneforpreventionofpostoperativenauseaandvomitinginpediatricstrabismussurgeryarandomizeddoubleblindtrial AT neerajkumar granisetronversusgranisetrondexamethasoneforpreventionofpostoperativenauseaandvomitinginpediatricstrabismussurgeryarandomizeddoubleblindtrial AT bikashranjanray granisetronversusgranisetrondexamethasoneforpreventionofpostoperativenauseaandvomitinginpediatricstrabismussurgeryarandomizeddoubleblindtrial AT virenderkumarmohan granisetronversusgranisetrondexamethasoneforpreventionofpostoperativenauseaandvomitinginpediatricstrabismussurgeryarandomizeddoubleblindtrial |
_version_ |
1724978747320303616 |