Numerical prediction of thrombosis risk in left atrium under atrial fibrillation
The remodeling of the left atrial morphology and function caused by atrial fibrillation (AF) can exacerbate thrombosis in the left atrium (LA) even spike up the risk of stroke within AF patients. This study explored the effect of the AF on hemodynamic and thrombosis in LA. We reconstructed the patie...
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doaj-050a67a9d4914cb890c3f79fa8e2db922021-07-21T06:47:47ZengAIMS PressMathematical Biosciences and Engineering1551-00182020-01-011732348236010.3934/mbe.2020125Numerical prediction of thrombosis risk in left atrium under atrial fibrillationYan Wang0Yonghui Qiao1Yankai Mao2Chenyang Jiang3Jianren Fan4Kun Luo 51. State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, China1. State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, China2. Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China 3. Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China3. Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China 4. Key Laboratory of Cardiovascular Medicine of Zhejiang Province, Hangzhou, China1. State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, China1. State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, ChinaThe remodeling of the left atrial morphology and function caused by atrial fibrillation (AF) can exacerbate thrombosis in the left atrium (LA) even spike up the risk of stroke within AF patients. This study explored the effect of the AF on hemodynamic and thrombosis in LA. We reconstructed the patient-specific anatomical shape of the LA and considered the non-Newtonian property of the blood. The thrombus model was applied in the LA models to simulate thrombosis. Our results indicate that AF can aggravate thrombosis which mainly occurs in the left atrial appendage (LAA). Thrombosis first forms on the LAA wall then expands toward the internal LAA. The proposed computational model also shows the potential application of numerical analyses to help assess the risk of thrombosis in AF patients.https://www.aimspress.com/article/doi/10.3934/mbe.2020125?viewType=HTMLatrial fibrillationleft atriumleft atrial appendagethrombosis risknon-newtoniancomputational fluid dynamics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Wang Yonghui Qiao Yankai Mao Chenyang Jiang Jianren Fan Kun Luo |
spellingShingle |
Yan Wang Yonghui Qiao Yankai Mao Chenyang Jiang Jianren Fan Kun Luo Numerical prediction of thrombosis risk in left atrium under atrial fibrillation Mathematical Biosciences and Engineering atrial fibrillation left atrium left atrial appendage thrombosis risk non-newtonian computational fluid dynamics |
author_facet |
Yan Wang Yonghui Qiao Yankai Mao Chenyang Jiang Jianren Fan Kun Luo |
author_sort |
Yan Wang |
title |
Numerical prediction of thrombosis risk in left atrium under atrial fibrillation |
title_short |
Numerical prediction of thrombosis risk in left atrium under atrial fibrillation |
title_full |
Numerical prediction of thrombosis risk in left atrium under atrial fibrillation |
title_fullStr |
Numerical prediction of thrombosis risk in left atrium under atrial fibrillation |
title_full_unstemmed |
Numerical prediction of thrombosis risk in left atrium under atrial fibrillation |
title_sort |
numerical prediction of thrombosis risk in left atrium under atrial fibrillation |
publisher |
AIMS Press |
series |
Mathematical Biosciences and Engineering |
issn |
1551-0018 |
publishDate |
2020-01-01 |
description |
The remodeling of the left atrial morphology and function caused by atrial fibrillation (AF) can exacerbate thrombosis in the left atrium (LA) even spike up the risk of stroke within AF patients. This study explored the effect of the AF on hemodynamic and thrombosis in LA. We reconstructed the patient-specific anatomical shape of the LA and considered the non-Newtonian property of the blood. The thrombus model was applied in the LA models to simulate thrombosis. Our results indicate that AF can aggravate thrombosis which mainly occurs in the left atrial appendage (LAA). Thrombosis first forms on the LAA wall then expands toward the internal LAA. The proposed computational model also shows the potential application of numerical analyses to help assess the risk of thrombosis in AF patients. |
topic |
atrial fibrillation left atrium left atrial appendage thrombosis risk non-newtonian computational fluid dynamics |
url |
https://www.aimspress.com/article/doi/10.3934/mbe.2020125?viewType=HTML |
work_keys_str_mv |
AT yanwang numericalpredictionofthrombosisriskinleftatriumunderatrialfibrillation AT yonghuiqiao numericalpredictionofthrombosisriskinleftatriumunderatrialfibrillation AT yankaimao numericalpredictionofthrombosisriskinleftatriumunderatrialfibrillation AT chenyangjiang numericalpredictionofthrombosisriskinleftatriumunderatrialfibrillation AT jianrenfan numericalpredictionofthrombosisriskinleftatriumunderatrialfibrillation AT kunluo numericalpredictionofthrombosisriskinleftatriumunderatrialfibrillation |
_version_ |
1721293019777335296 |