The implication of omega-3 polyunsaturated fatty acids in retinal physiology

Neuronal tissues such as the retina and the brain are characterized by their high content in phospholipids. In the retina, phospholipids can account for until 80% of total lipids and are mainly composed by species belonging to phosphatidyl-choline and phosphatidyl-ethanolamine sub-classes. Within fa...

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Main Author: Acar Niyazi
Format: Article
Language:English
Published: EDP Sciences 2007-05-01
Series:Oléagineux, Corps gras, Lipides
Subjects:
Online Access:http://dx.doi.org/10.1051/ocl.2007.0121
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spelling doaj-0514cda9df2e42408d84f9cf4dbbc84e2021-04-02T09:41:30ZengEDP SciencesOléagineux, Corps gras, Lipides1258-82101950-697X2007-05-01143-419419710.1051/ocl.2007.0121ocl2007143-4p194The implication of omega-3 polyunsaturated fatty acids in retinal physiologyAcar NiyaziNeuronal tissues such as the retina and the brain are characterized by their high content in phospholipids. In the retina, phospholipids can account for until 80% of total lipids and are mainly composed by species belonging to phosphatidyl-choline and phosphatidyl-ethanolamine sub-classes. Within fatty acids esterified on retinal phospholipids, omega-3 PUFAs are major components since docosahexaenoic acid (DHA) can represent until 50% of total fatty acids in the photoreceptor outer segments. For long time, DHA is known to play a major role in membrane function and subsequently in visual processes by affecting permeability, fluidity, thickness and the activation of membrane-bound proteins. Today, more and more studies show that PUFAs from the omega-3 series may also operate as protective factors in retinal vascular and immuno-regulatory processes, in maintaining the physiologic redox balance and in cell survival. They may operate within complex systems involving eicosanoids, angiogenic factors, inflammatory factors and matrix metalloproteinases. This new and emerging concept based on the interrelationship of omega-3 PUFAs with neural and vascular structure and function appears to be essential when considering retinal diseases of public health significance such as age-related macular degeneration.http://dx.doi.org/10.1051/ocl.2007.0121Omega-3 polyunsaturated fatty acidsretinaoxidative stressinflammationvasculogenesis
collection DOAJ
language English
format Article
sources DOAJ
author Acar Niyazi
spellingShingle Acar Niyazi
The implication of omega-3 polyunsaturated fatty acids in retinal physiology
Oléagineux, Corps gras, Lipides
Omega-3 polyunsaturated fatty acids
retina
oxidative stress
inflammation
vasculogenesis
author_facet Acar Niyazi
author_sort Acar Niyazi
title The implication of omega-3 polyunsaturated fatty acids in retinal physiology
title_short The implication of omega-3 polyunsaturated fatty acids in retinal physiology
title_full The implication of omega-3 polyunsaturated fatty acids in retinal physiology
title_fullStr The implication of omega-3 polyunsaturated fatty acids in retinal physiology
title_full_unstemmed The implication of omega-3 polyunsaturated fatty acids in retinal physiology
title_sort implication of omega-3 polyunsaturated fatty acids in retinal physiology
publisher EDP Sciences
series Oléagineux, Corps gras, Lipides
issn 1258-8210
1950-697X
publishDate 2007-05-01
description Neuronal tissues such as the retina and the brain are characterized by their high content in phospholipids. In the retina, phospholipids can account for until 80% of total lipids and are mainly composed by species belonging to phosphatidyl-choline and phosphatidyl-ethanolamine sub-classes. Within fatty acids esterified on retinal phospholipids, omega-3 PUFAs are major components since docosahexaenoic acid (DHA) can represent until 50% of total fatty acids in the photoreceptor outer segments. For long time, DHA is known to play a major role in membrane function and subsequently in visual processes by affecting permeability, fluidity, thickness and the activation of membrane-bound proteins. Today, more and more studies show that PUFAs from the omega-3 series may also operate as protective factors in retinal vascular and immuno-regulatory processes, in maintaining the physiologic redox balance and in cell survival. They may operate within complex systems involving eicosanoids, angiogenic factors, inflammatory factors and matrix metalloproteinases. This new and emerging concept based on the interrelationship of omega-3 PUFAs with neural and vascular structure and function appears to be essential when considering retinal diseases of public health significance such as age-related macular degeneration.
topic Omega-3 polyunsaturated fatty acids
retina
oxidative stress
inflammation
vasculogenesis
url http://dx.doi.org/10.1051/ocl.2007.0121
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