Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy
Оn-pump coronary bypass surgery was performed in 58 stable angina patients aged 43-72. Group I (n = 19) received standard coronary heart disease (CHD) treatment, together with mildronate: before the surgery, 750 mg/d for 3 days, then 750 mg/d twice a week. Group II (n = 19) received standard therapy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2005-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2492 |
| Summary: | Оn-pump coronary bypass surgery was performed in 58 stable angina patients aged 43-72. Group I (n = 19) received standard coronary heart disease (CHD) treatment, together with mildronate: before the surgery, 750 mg/d for 3 days, then 750 mg/d twice a week. Group II (n = 19) received standard therapy, plus trimethazidine (Preductal MB), 70 mg/d. Group III (n = 20) did not receive any metabolic medications. Dynamics of lipid peroxidation and protective antioxidant systems status was assessed during first 24 hours after surgery. Blood samples were collected before the intervention, 6 and 24 hours later. Cardioprotectors mildronate and trimethazidin, administered before surgery, decreased blood levels of lipid peroxidation products, due to activation of protective antioxidant enzymes - superoxide dismutase (SOD) and glutathione peroxidase (GP). |
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| ISSN: | 1560-4071 2618-7620 |