Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeut...
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Bibliographic Details
| Main Authors: |
Alyssa Vito,
Omar Salem,
Nader El-Sayes,
Ian P. MacFawn,
Ana L. Portillo,
Katy Milne,
Danielle Harrington,
Ali A. Ashkar,
Yonghong Wan,
Samuel T. Workenhe,
Brad H. Nelson,
Tullia C. Bruno,
Karen L. Mossman |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-07-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-021-02375-9
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