DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization
Construction and physico-chemical behavior of DNA three way junction (3WJ) functionalized by protein-like residues (imidazole, alcohol and carboxylic acid) at unpaired positions at the core is described. One 5′-C(S)-propargyl-thymidine nucleotide was specifically incorporated on each strand to react...
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2016-08-01
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doaj-052cab37364e45a380436787d10fb66e2020-11-24T20:40:14ZengMDPI AGMolecules1420-30492016-08-01219108210.3390/molecules21091082molecules21091082DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and CharacterizationClaudia Addamiano0Béatrice Gerland1Corinne Payrastre2Jean-Marc Escudier3Laboratoire de Synthèse et Physico-Chimie de Molécules d′Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, Cedex 9, Toulouse 31062, FranceLaboratoire de Synthèse et Physico-Chimie de Molécules d′Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, Cedex 9, Toulouse 31062, FranceLaboratoire de Synthèse et Physico-Chimie de Molécules d′Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, Cedex 9, Toulouse 31062, FranceLaboratoire de Synthèse et Physico-Chimie de Molécules d′Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, Cedex 9, Toulouse 31062, FranceConstruction and physico-chemical behavior of DNA three way junction (3WJ) functionalized by protein-like residues (imidazole, alcohol and carboxylic acid) at unpaired positions at the core is described. One 5′-C(S)-propargyl-thymidine nucleotide was specifically incorporated on each strand to react through a post synthetic CuACC reaction with either protected imidazolyl-, hydroxyl- or carboxyl-azide. Structural impacts of 5′-C(S)-functionalization were investigated to evaluate how 3WJ flexibility/stability is affected.http://www.mdpi.com/1420-3049/21/9/1082three way junctionconvertible nucleotideCuACCchemically modified oligonucleotides |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia Addamiano Béatrice Gerland Corinne Payrastre Jean-Marc Escudier |
spellingShingle |
Claudia Addamiano Béatrice Gerland Corinne Payrastre Jean-Marc Escudier DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization Molecules three way junction convertible nucleotide CuACC chemically modified oligonucleotides |
author_facet |
Claudia Addamiano Béatrice Gerland Corinne Payrastre Jean-Marc Escudier |
author_sort |
Claudia Addamiano |
title |
DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization |
title_short |
DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization |
title_full |
DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization |
title_fullStr |
DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization |
title_full_unstemmed |
DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization |
title_sort |
dna three way junction core decorated with amino acids-like residues-synthesis and characterization |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2016-08-01 |
description |
Construction and physico-chemical behavior of DNA three way junction (3WJ) functionalized by protein-like residues (imidazole, alcohol and carboxylic acid) at unpaired positions at the core is described. One 5′-C(S)-propargyl-thymidine nucleotide was specifically incorporated on each strand to react through a post synthetic CuACC reaction with either protected imidazolyl-, hydroxyl- or carboxyl-azide. Structural impacts of 5′-C(S)-functionalization were investigated to evaluate how 3WJ flexibility/stability is affected. |
topic |
three way junction convertible nucleotide CuACC chemically modified oligonucleotides |
url |
http://www.mdpi.com/1420-3049/21/9/1082 |
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1716827795051511808 |