Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
Abstract.: A better understanding of the neurochemical mechanisms mediating the aversive consequences of drug withdrawal is important for understanding drug addiction. We previously demonstrated that the inhibitory effect of glutamate receptor antagonists on the conditioned place aversion (CPA) indu...
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doaj-0535185596404c27af9459c137db45a82020-11-24T21:49:18ZengElsevierJournal of Pharmacological Sciences1347-86132011-01-0111712733Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated RatsYoichi Kawasaki0Hiroaki Araki1Katsuya Suemaru2Yoshihisa Kitamura3Yutaka Gomita4Toshiaki Sendo5Department of Pharmacy, Okayama University Hospital, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, JapanDivision of Pharmacy, Ehime University Hospital, Shitsukawa, Toon, Ehime 791-0295, Japan; Corresponding author. haraki@m.ehime-u.ac.jpDivision of Pharmacy, Ehime University Hospital, Shitsukawa, Toon, Ehime 791-0295, JapanDepartment of Pharmacy, Okayama University Hospital, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, JapanSchool of Pharmacy, Shujitsu University, 1-6-1, Nishigawara, Naka-ku, Okayama 703-8516, JapanDepartment of Pharmacy, Okayama University Hospital, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, JapanAbstract.: A better understanding of the neurochemical mechanisms mediating the aversive consequences of drug withdrawal is important for understanding drug addiction. We previously demonstrated that the inhibitory effect of glutamate receptor antagonists on the conditioned place aversion (CPA) induced by naloxone-precipitated withdrawal after a single morphine exposure could be blocked by dopamine receptor antagonists. Thus, a glutamatergic–dopaminergic interaction may participate in this phenomenon. The current study was undertaken to further characterize this interaction by employing both D1 (SCH 23390) and D2 (raclopride and eticlopride) dopamine receptor antagonists. The influence of these antagonists on the attenuation of CPA by MK-801 (NMDA receptor antagonist), GYKI 52466 (AMPA receptor antagonist), and MCPG (metabotropic glutamate receptor antagonist) was determined in rats receiving a single dose of morphine. The dopamine antagonists showed either a significant reversal or a tendency to reverse the effects of MK-801 on CPA. The effect of GYKI 52466 was also attenuated by the blockade of either D1 or D2 receptors. The effect of MCPG, however, was only blocked by D2 antagonists and not by the D1 antagonist SCH 23390. These results add evidence to the hypothesis that a glutamatergic–dopaminergic interaction may be involved in the CPA induced by naloxone-precipitated withdrawal following a single morphine exposure and suggest that both D1 and D2 dopamine receptor signaling mechanisms play a role in mediating the aversive aspects of acute dependence. Keywords:: morphine, acute dependence, conditioned place aversion, glutamatergic, dopaminergichttp://www.sciencedirect.com/science/article/pii/S1347861319306577 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoichi Kawasaki Hiroaki Araki Katsuya Suemaru Yoshihisa Kitamura Yutaka Gomita Toshiaki Sendo |
spellingShingle |
Yoichi Kawasaki Hiroaki Araki Katsuya Suemaru Yoshihisa Kitamura Yutaka Gomita Toshiaki Sendo Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats Journal of Pharmacological Sciences |
author_facet |
Yoichi Kawasaki Hiroaki Araki Katsuya Suemaru Yoshihisa Kitamura Yutaka Gomita Toshiaki Sendo |
author_sort |
Yoichi Kawasaki |
title |
Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats |
title_short |
Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats |
title_full |
Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats |
title_fullStr |
Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats |
title_full_unstemmed |
Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats |
title_sort |
involvement of dopaminergic receptor signaling in the effects of glutamatergic receptor antagonists on conditioned place aversion induced by naloxone in single-dose morphine-treated rats |
publisher |
Elsevier |
series |
Journal of Pharmacological Sciences |
issn |
1347-8613 |
publishDate |
2011-01-01 |
description |
Abstract.: A better understanding of the neurochemical mechanisms mediating the aversive consequences of drug withdrawal is important for understanding drug addiction. We previously demonstrated that the inhibitory effect of glutamate receptor antagonists on the conditioned place aversion (CPA) induced by naloxone-precipitated withdrawal after a single morphine exposure could be blocked by dopamine receptor antagonists. Thus, a glutamatergic–dopaminergic interaction may participate in this phenomenon. The current study was undertaken to further characterize this interaction by employing both D1 (SCH 23390) and D2 (raclopride and eticlopride) dopamine receptor antagonists. The influence of these antagonists on the attenuation of CPA by MK-801 (NMDA receptor antagonist), GYKI 52466 (AMPA receptor antagonist), and MCPG (metabotropic glutamate receptor antagonist) was determined in rats receiving a single dose of morphine. The dopamine antagonists showed either a significant reversal or a tendency to reverse the effects of MK-801 on CPA. The effect of GYKI 52466 was also attenuated by the blockade of either D1 or D2 receptors. The effect of MCPG, however, was only blocked by D2 antagonists and not by the D1 antagonist SCH 23390. These results add evidence to the hypothesis that a glutamatergic–dopaminergic interaction may be involved in the CPA induced by naloxone-precipitated withdrawal following a single morphine exposure and suggest that both D1 and D2 dopamine receptor signaling mechanisms play a role in mediating the aversive aspects of acute dependence. Keywords:: morphine, acute dependence, conditioned place aversion, glutamatergic, dopaminergic |
url |
http://www.sciencedirect.com/science/article/pii/S1347861319306577 |
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