Interferon Regulatory Factor 9 Structure and Regulation
Interferon regulatory factor 9 (IRF9) is an integral transcription factor in mediating the type I interferon antiviral response, as part of the interferon-stimulated gene factor 3. However, the role of IRF9 in many important non-communicable diseases has just begun to emerge. The duality of IRF9’s r...
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doaj-0539ec4d786d4b33a975fbeaabce3ca32020-11-24T21:38:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-08-01910.3389/fimmu.2018.01831396553Interferon Regulatory Factor 9 Structure and RegulationAlvin PaulThean Hock TangSiew Kit NgInterferon regulatory factor 9 (IRF9) is an integral transcription factor in mediating the type I interferon antiviral response, as part of the interferon-stimulated gene factor 3. However, the role of IRF9 in many important non-communicable diseases has just begun to emerge. The duality of IRF9’s role in conferring protection but at the same time exacerbates diseases is certainly puzzling. The regulation of IRF9 during these conditions is not well understood. The high homology of IRF9 DNA-binding domain to other IRFs, as well as the recently resolved IRF9 IRF-associated domain structure can provide the necessary insights for progressive inroads on understanding the regulatory mechanism of IRF9. This review sought to outline the structural basis of IRF9 that guides its regulation and interaction in antiviral immunity and other diseases.https://www.frontiersin.org/article/10.3389/fimmu.2018.01831/fullinterferon regulatory factor 9JAK-STATtype I interferonsinnate immunityinterferon-stimulated genesantiviral defense |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alvin Paul Thean Hock Tang Siew Kit Ng |
spellingShingle |
Alvin Paul Thean Hock Tang Siew Kit Ng Interferon Regulatory Factor 9 Structure and Regulation Frontiers in Immunology interferon regulatory factor 9 JAK-STAT type I interferons innate immunity interferon-stimulated genes antiviral defense |
author_facet |
Alvin Paul Thean Hock Tang Siew Kit Ng |
author_sort |
Alvin Paul |
title |
Interferon Regulatory Factor 9 Structure and Regulation |
title_short |
Interferon Regulatory Factor 9 Structure and Regulation |
title_full |
Interferon Regulatory Factor 9 Structure and Regulation |
title_fullStr |
Interferon Regulatory Factor 9 Structure and Regulation |
title_full_unstemmed |
Interferon Regulatory Factor 9 Structure and Regulation |
title_sort |
interferon regulatory factor 9 structure and regulation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-08-01 |
description |
Interferon regulatory factor 9 (IRF9) is an integral transcription factor in mediating the type I interferon antiviral response, as part of the interferon-stimulated gene factor 3. However, the role of IRF9 in many important non-communicable diseases has just begun to emerge. The duality of IRF9’s role in conferring protection but at the same time exacerbates diseases is certainly puzzling. The regulation of IRF9 during these conditions is not well understood. The high homology of IRF9 DNA-binding domain to other IRFs, as well as the recently resolved IRF9 IRF-associated domain structure can provide the necessary insights for progressive inroads on understanding the regulatory mechanism of IRF9. This review sought to outline the structural basis of IRF9 that guides its regulation and interaction in antiviral immunity and other diseases. |
topic |
interferon regulatory factor 9 JAK-STAT type I interferons innate immunity interferon-stimulated genes antiviral defense |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2018.01831/full |
work_keys_str_mv |
AT alvinpaul interferonregulatoryfactor9structureandregulation AT theanhocktang interferonregulatoryfactor9structureandregulation AT siewkitng interferonregulatoryfactor9structureandregulation |
_version_ |
1725935451443822592 |