Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown

Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown

Chemokines (C-X-C) motif ligand (CXCL) 5 and 8 are overexpressed in patients with multiple sclerosis, where CXCL5 serum levels were shown to correlate with blood–brain barrier dysfunction as evidenced by gadolinium-enhanced magnetic resonance imaging. Here, we studied the potential role of CXCL5/CXC...

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Bibliographic Details
Main Authors: Axel Haarmann, Michael K. Schuhmann, Christine Silwedel, Camelia-Maria Monoranu, Guido Stoll, Mathias Buttmann
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain barrier
multiple sclerosis
human cerebral endothelial cells
CXCR2
CXCL5
CXCL8
interleukin-8
SB332235
Online Access:https://www.mdpi.com/1422-0067/20/3/602

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