Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells

Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response (DDR) at the S and G2/M cell cycle checkpoints, and plays a crucial role in preserving genomic integrity. CHK1 overexpression is thought to contribute to cancer aggressiveness, and several selective inhibitors of this kinase...

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Bibliographic Details
Main Authors: Kiyohiro Ando, Yohko Nakamura, Hiroki Nagase, Akira Nakagawara, Tsugumichi Koshinaga, Satoshi Wada, Makoto Makishima
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
CHK1
ATM
DNA-PK
neuroblastoma
checkpoint abrogation
Online Access:https://www.mdpi.com/1422-0067/20/15/3700

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