Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units
Heater Cooler Units (HCUs) are frequently used not only during heart surgery but also in ECMO therapy to regulate the blood temperature of patients. It is known from cardiac surgery that the water circuits of HCUs can be bacterially contaminated and under adverse conditions can lead to a nosocomial...
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De Gruyter
2020-09-01
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Online Access: | https://doi.org/10.1515/cdbme-2020-3074 |
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doaj-055aaa9dd2cb411ea3e332ea2814e2182021-09-06T19:19:29ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042020-09-016329229410.1515/cdbme-2020-3074cdbme-2020-3074Proof of Concept for Ozone-Based Disinfection of Heater Cooler UnitsMarkus Bongert0Jan Wüst1Justus Strauch2Dirk Buchwald3University of Applied Sciences and Arts, Research Center for BioMedical Technology (BMT), Sonnenstr. 96,Dortmund, GermanyUniversity of Applied Sciences and Arts, Research Center for Computersimulation, Sonnenstr. 96,Dortmund, GermanyRuhr-University Bochum, University Hospital Bergmannsheil, Clinic for Heart- and Thoracic Surgery,Bochum, GermanyRuhr-University Bochum, University Hospital Bergmannsheil, Clinic for Heart- and Thoracic Surgery,Bochum, GermanyHeater Cooler Units (HCUs) are frequently used not only during heart surgery but also in ECMO therapy to regulate the blood temperature of patients. It is known from cardiac surgery that the water circuits of HCUs can be bacterially contaminated and under adverse conditions can lead to a nosocomial infection of the patient. The addition of chemical disinfectants to the water of HCUs is problematic. In addition, it is an increasingly significant cost factor due to the required material and personnel input. The aim of this research project is both the development of an automated device for disinfecting water in HCUs and proof of its effectiveness. The device is based on ozone, a substance with known antimicrobial properties. To prevent ozone from coming into contact with the HCU components, the water is irradiated with UV light (254nm). Two bypasses and ozone sensors guarantee a complete elimination of residual ozone. The effectiveness of the device was tested by series of experiments with the surrogate germ, Pseudomonas aeruginosa. The device allows a wide range of ozone concentrations and exposure times to be selected. In previous test series, it has been shown both that a reduction of the bacterial count to drinking water quality can be achieved with a treatment time of only one hour, and that self-cleaning can be carried out effectively before clinical use, and in standby mode. Attention must be paid to the water quality in HCUs as a potential source of infection, regardless of where they are used. The "proof of concept" showed an excellent disinfection effect with simultaneous elimination of excess ozone to drinking water levels. The number of indicator bacteria in the water tank of the dummy HCU was reduced by approx. 98% after only 30 minutes.https://doi.org/10.1515/cdbme-2020-3074heater cooler unitdisinfectionozoneecmomycobacterium chimaeracomputational fluid dynamicsexperimental rig “o3desi” |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Markus Bongert Jan Wüst Justus Strauch Dirk Buchwald |
spellingShingle |
Markus Bongert Jan Wüst Justus Strauch Dirk Buchwald Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units Current Directions in Biomedical Engineering heater cooler unit disinfection ozone ecmo mycobacterium chimaera computational fluid dynamics experimental rig “o3desi” |
author_facet |
Markus Bongert Jan Wüst Justus Strauch Dirk Buchwald |
author_sort |
Markus Bongert |
title |
Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units |
title_short |
Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units |
title_full |
Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units |
title_fullStr |
Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units |
title_full_unstemmed |
Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units |
title_sort |
proof of concept for ozone-based disinfection of heater cooler units |
publisher |
De Gruyter |
series |
Current Directions in Biomedical Engineering |
issn |
2364-5504 |
publishDate |
2020-09-01 |
description |
Heater Cooler Units (HCUs) are frequently used not only during heart surgery but also in ECMO therapy to regulate the blood temperature of patients. It is known from cardiac surgery that the water circuits of HCUs can be bacterially contaminated and under adverse conditions can lead to a nosocomial infection of the patient. The addition of chemical disinfectants to the water of HCUs is problematic. In addition, it is an increasingly significant cost factor due to the required material and personnel input. The aim of this research project is both the development of an automated device for disinfecting water in HCUs and proof of its effectiveness. The device is based on ozone, a substance with known antimicrobial properties. To prevent ozone from coming into contact with the HCU components, the water is irradiated with UV light (254nm). Two bypasses and ozone sensors guarantee a complete elimination of residual ozone. The effectiveness of the device was tested by series of experiments with the surrogate germ, Pseudomonas aeruginosa. The device allows a wide range of ozone concentrations and exposure times to be selected. In previous test series, it has been shown both that a reduction of the bacterial count to drinking water quality can be achieved with a treatment time of only one hour, and that self-cleaning can be carried out effectively before clinical use, and in standby mode. Attention must be paid to the water quality in HCUs as a potential source of infection, regardless of where they are used. The "proof of concept" showed an excellent disinfection effect with simultaneous elimination of excess ozone to drinking water levels. The number of indicator bacteria in the water tank of the dummy HCU was reduced by approx. 98% after only 30 minutes. |
topic |
heater cooler unit disinfection ozone ecmo mycobacterium chimaera computational fluid dynamics experimental rig “o3desi” |
url |
https://doi.org/10.1515/cdbme-2020-3074 |
work_keys_str_mv |
AT markusbongert proofofconceptforozonebaseddisinfectionofheatercoolerunits AT janwust proofofconceptforozonebaseddisinfectionofheatercoolerunits AT justusstrauch proofofconceptforozonebaseddisinfectionofheatercoolerunits AT dirkbuchwald proofofconceptforozonebaseddisinfectionofheatercoolerunits |
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