Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation
Summary: Both genetic variations and nutritional deficiency are associated with autism spectrum disorders and other neurological disorders. However, it is less clear whether or how nutritional deficiency and genetic variations influence each other under pathogenic conditions. “Valosin-containing pro...
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doaj-056428542bc84c8fbd6a468379699fa52021-01-24T04:28:52ZengElsevieriScience2589-00422021-01-01241101949Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementationTzyy-Nan Huang0Yu-Tzu Shih1Si-Cih Lin2Yi-Ping Hsueh3Institute of Molecular Biology, Academia Sinica, 128, Academia Road, Section 2, Taipei 11529, Taiwan, Republic of ChinaInstitute of Molecular Biology, Academia Sinica, 128, Academia Road, Section 2, Taipei 11529, Taiwan, Republic of ChinaInstitute of Molecular Biology, Academia Sinica, 128, Academia Road, Section 2, Taipei 11529, Taiwan, Republic of ChinaInstitute of Molecular Biology, Academia Sinica, 128, Academia Road, Section 2, Taipei 11529, Taiwan, Republic of China; Corresponding authorSummary: Both genetic variations and nutritional deficiency are associated with autism spectrum disorders and other neurological disorders. However, it is less clear whether or how nutritional deficiency and genetic variations influence each other under pathogenic conditions. “Valosin-containing protein” (VCP, also known as p97) is associated with multiple neurological disorders and regulates dendritic spine formation by controlling endoplasmic reticulum formation and protein synthesis efficiency. Increased protein synthesis ameliorates the dendritic spine defects of Vcp-deficient neurons. Therefore, we investigated if Vcp-deficient mice are sensitive to nutritional conditions. Here, we show that social interaction and contextual memory of Vcp-deficient mice are indeed influenced by different dietary protein levels. Moreover, leucine supplementation ameliorates the behavioral deficits and dendritic spine density of Vcp-deficient mice, strengthening evidence for the role of protein synthesis in VCP function. Our study illustrates that genetic variation and nutrient factors cross-talk to influence neuronal and behavioral phenotypes.http://www.sciencedirect.com/science/article/pii/S2589004220311469Biological SciencesNeuroscienceBehavioral Neuroscience |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tzyy-Nan Huang Yu-Tzu Shih Si-Cih Lin Yi-Ping Hsueh |
spellingShingle |
Tzyy-Nan Huang Yu-Tzu Shih Si-Cih Lin Yi-Ping Hsueh Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation iScience Biological Sciences Neuroscience Behavioral Neuroscience |
author_facet |
Tzyy-Nan Huang Yu-Tzu Shih Si-Cih Lin Yi-Ping Hsueh |
author_sort |
Tzyy-Nan Huang |
title |
Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation |
title_short |
Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation |
title_full |
Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation |
title_fullStr |
Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation |
title_full_unstemmed |
Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation |
title_sort |
social behaviors and contextual memory of vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2021-01-01 |
description |
Summary: Both genetic variations and nutritional deficiency are associated with autism spectrum disorders and other neurological disorders. However, it is less clear whether or how nutritional deficiency and genetic variations influence each other under pathogenic conditions. “Valosin-containing protein” (VCP, also known as p97) is associated with multiple neurological disorders and regulates dendritic spine formation by controlling endoplasmic reticulum formation and protein synthesis efficiency. Increased protein synthesis ameliorates the dendritic spine defects of Vcp-deficient neurons. Therefore, we investigated if Vcp-deficient mice are sensitive to nutritional conditions. Here, we show that social interaction and contextual memory of Vcp-deficient mice are indeed influenced by different dietary protein levels. Moreover, leucine supplementation ameliorates the behavioral deficits and dendritic spine density of Vcp-deficient mice, strengthening evidence for the role of protein synthesis in VCP function. Our study illustrates that genetic variation and nutrient factors cross-talk to influence neuronal and behavioral phenotypes. |
topic |
Biological Sciences Neuroscience Behavioral Neuroscience |
url |
http://www.sciencedirect.com/science/article/pii/S2589004220311469 |
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