GABAB Receptors Do Not Mediate the Inhibitory Actions of Gabapentin on the Spinal Reflex in Rats
The clinical effectiveness of gabapentin for the treatment of epilepsy, spasticity, and neuropathic pain has been established. The mechanisms responsible for those actions, however, are still not clearly understood. We have recently demonstrated that gabapentin reduces the spinal reflex in rats via...
Main Authors: | Shinobu Shimizu, Motoko Honda, Mitsuo Tanabe, Hideki Ono |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2004-01-01
|
Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319323230 |
Similar Items
-
Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats
by: Shinobu Shimizu, et al.
Published: (2004-01-01) -
Involvement of Supraspinal Imidazoline Receptors and Descending Monoaminergic Pathways in Tizanidine-Induced Inhibition of Rat Spinal Reflexes
by: Yurika Kino, et al.
Published: (2005-01-01) -
Enhanced Wind-Up of the C-Fiber-Mediated Nociceptive Flexor Reflex Movement Following Painful Diabetic Neuropathy in Mice
by: Satoko Kimura, et al.
Published: (2005-01-01) -
Noxious Stimuli Evoke a Biphasic Flexor Reflex Composed of A δ-Fiber-Mediated Short-Latency and C-Fiber-Mediated Long-Latency Withdrawal Movements in Mice
by: Satoko Kimura, et al.
Published: (2004-01-01) -
Protein Kinase A–Dependence of the Supraspinally Mediated Analgesic Effects of Gabapentin on Thermal and Mechanical Hypersensitivity
by: Keiko Takasu, et al.
Published: (2009-01-01)