Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling
Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. A...
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doaj-05700dd003044464acfada43c55990b72020-11-25T00:21:09ZengHindawi LimitedCardiology Research and Practice2090-80162090-05972016-01-01201610.1155/2016/35823803582380Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease ModelingDaniel R. Bayzigitov0Sergey P. Medvedev1Elena V. Dementyeva2Sevda A. Bayramova3Evgeny A. Pokushalov4Alexander M. Karaskov5Suren M. Zakian6Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, RussiaFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, RussiaFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, RussiaState Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, RussiaState Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, RussiaState Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, RussiaFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, RussiaFundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.http://dx.doi.org/10.1155/2016/3582380 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel R. Bayzigitov Sergey P. Medvedev Elena V. Dementyeva Sevda A. Bayramova Evgeny A. Pokushalov Alexander M. Karaskov Suren M. Zakian |
spellingShingle |
Daniel R. Bayzigitov Sergey P. Medvedev Elena V. Dementyeva Sevda A. Bayramova Evgeny A. Pokushalov Alexander M. Karaskov Suren M. Zakian Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling Cardiology Research and Practice |
author_facet |
Daniel R. Bayzigitov Sergey P. Medvedev Elena V. Dementyeva Sevda A. Bayramova Evgeny A. Pokushalov Alexander M. Karaskov Suren M. Zakian |
author_sort |
Daniel R. Bayzigitov |
title |
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling |
title_short |
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling |
title_full |
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling |
title_fullStr |
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling |
title_full_unstemmed |
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling |
title_sort |
human induced pluripotent stem cell-derived cardiomyocytes afford new opportunities in inherited cardiovascular disease modeling |
publisher |
Hindawi Limited |
series |
Cardiology Research and Practice |
issn |
2090-8016 2090-0597 |
publishDate |
2016-01-01 |
description |
Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes. |
url |
http://dx.doi.org/10.1155/2016/3582380 |
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