<em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm Leaves
A new triterpene glycoside, 3-<em>O</em>-[(<em>α</em>-L-rhamnopyranosyl)(1→2)]-[<em>β</em>-D-glucuronopyranosyl-6-<em>O</em>-methyl ester]-olean-12-ene-28-olic acid (<strong>...
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doaj-0575d35d1b534bf599dd3fe87bd555f52020-11-24T23:05:19ZengMDPI AGMolecules1420-30492012-05-011766269627610.3390/molecules17066269<em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm LeavesHai-Xue KuangYong-Gang XiaHai JiangZhi-Bin WangBing-You YangA new triterpene glycoside, 3-<em>O</em>-[(<em>α</em>-L-rhamnopyranosyl)(1→2)]-[<em>β</em>-D-glucuronopyranosyl-6-<em>O</em>-methyl ester]-olean-12-ene-28-olic acid (<strong>1</strong>) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (<strong>5</strong>) were isolated from the leaves of <em>Acanthopanax senticosus</em> Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound <strong>6</strong> showed significant <em>α</em>-glucosidase inhibition activity.http://www.mdpi.com/1420-3049/17/6/6269<em>Acanthopanax senticosus</em> Harmstriterpene glycosidealkaloid<em>α</em>-glucosidase inhibition activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hai-Xue Kuang Yong-Gang Xia Hai Jiang Zhi-Bin Wang Bing-You Yang |
spellingShingle |
Hai-Xue Kuang Yong-Gang Xia Hai Jiang Zhi-Bin Wang Bing-You Yang <em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm Leaves Molecules <em>Acanthopanax senticosus</em> Harms triterpene glycoside alkaloid <em>α</em>-glucosidase inhibition activity |
author_facet |
Hai-Xue Kuang Yong-Gang Xia Hai Jiang Zhi-Bin Wang Bing-You Yang |
author_sort |
Hai-Xue Kuang |
title |
<em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm Leaves |
title_short |
<em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm Leaves |
title_full |
<em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm Leaves |
title_fullStr |
<em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm Leaves |
title_full_unstemmed |
<em>α</em>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosus</em> Harm Leaves |
title_sort |
<em>α</em>-glucosidase inhibitory constituents from <em>acanthopanax senticosus</em> harm leaves |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2012-05-01 |
description |
A new triterpene glycoside, 3-<em>O</em>-[(<em>α</em>-L-rhamnopyranosyl)(1→2)]-[<em>β</em>-D-glucuronopyranosyl-6-<em>O</em>-methyl ester]-olean-12-ene-28-olic acid (<strong>1</strong>) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (<strong>5</strong>) were isolated from the leaves of <em>Acanthopanax senticosus</em> Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound <strong>6</strong> showed significant <em>α</em>-glucosidase inhibition activity. |
topic |
<em>Acanthopanax senticosus</em> Harms triterpene glycoside alkaloid <em>α</em>-glucosidase inhibition activity |
url |
http://www.mdpi.com/1420-3049/17/6/6269 |
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