Tetrahydrobiopterin Synthesis in Rat Cardiac Myocytes; An Event Required for Cytokine-induced NO Generation

Tetrahydrobiopterin Synthesis in Rat Cardiac Myocytes; An Event Required for Cytokine-induced NO Generation

Cardiac myocytes are known to express the high-capacity inducible isoform of nitric oxide (NO) synthase (iNOS). Since tetrahydrobiopterin (BH4) is an essential cofactor for NO formation, we investigated whether BH4 synthesis is required for cytokine-induced NO production in cultutred rat cardiac myo...

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Bibliographic Details
Main Authors: Hattori Yoshiyuki, Nakanishi Nobuo, Gross Steven S., Kasai Kikuo
Format: Article
Language:English
Published: De Gruyter 1998-02-01
Series:Pteridines
Subjects:
nitric oxide synthase
gtp cyclohydrolase i
heart
Online Access:https://doi.org/10.1515/pteridines.1998.9.1.8

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