Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function
Introduction: Cisplatin is one of the most potent chemotherapeutic antitumor drugs. Also, oxidative stress has been established to be involved in cisplatin-induced toxicity. Therefore, the present study was undertaken to examine the antioxidant and anti-inflammation potential of green tea hydroalcoh...
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doaj-0584c604a5d6406f93055e898488d66b2021-08-02T02:25:58ZengNikan Research InstituteJournal of HerbMed Pharmacology2345-50042016-07-015399102JHP_1012_20160106121949Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver functionNilofar Amidi0Shirin Moradkhani1Mahsa Sedaghat2Nejat Khiripour3Amir Larki-Harchegani4Nahid Zadkhosh5Mahmoud Mirhoseini6Akram Ranjbar7Student Research Center, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Pharmacognosy and pharmaceutical biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Pharmacognosy and pharmaceutical biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranStudent Research Center, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranMedical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranIntroduction: Cisplatin is one of the most potent chemotherapeutic antitumor drugs. Also, oxidative stress has been established to be involved in cisplatin-induced toxicity. Therefore, the present study was undertaken to examine the antioxidant and anti-inflammation potential of green tea hydroalcoholic extract (GTE) against the liver function of cisplatin in male rats. Methods: Adult male Wistar rats (180–250 g) were divided into 4 groups (n = 5) treated as follows: (1) control group (saline solution, 1 ml kg−1 body weight, i.p.), cisplatin group (7 mg kg−1 body weight, i.p.). Animals of Groups III received only green tea extract (30 mg/kg/day, by gavage). Group IV was given green tea extract+ cisplatin once daily for 24 hours. Liver function was evidenced in the cisplatin group by the increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The mechanism of cisplatin induced liver function was considered as being decreased the total antioxidant power (TAP). Systemic inflammation was assessed by tumor necrosis factor-alpha (TNF-α) levels. Results: A decrease in TAP level in cisplatin group was observed compared with control group. GTE administration decreased TNF-α and increased TAP compared to cisplatin group, but showed no significant differences between groups. Conclusion: The results suggested that green tea could ameliorate cisplatin liver function in rats through reduction of oxidative toxic stress and inflammation.http://herbmedpharmacol.com/PDF/JHP_1012_20160106121949CisplatinGreen teaInflammationLiver functionOxidative toxic stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nilofar Amidi Shirin Moradkhani Mahsa Sedaghat Nejat Khiripour Amir Larki-Harchegani Nahid Zadkhosh Mahmoud Mirhoseini Akram Ranjbar |
spellingShingle |
Nilofar Amidi Shirin Moradkhani Mahsa Sedaghat Nejat Khiripour Amir Larki-Harchegani Nahid Zadkhosh Mahmoud Mirhoseini Akram Ranjbar Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function Journal of HerbMed Pharmacology Cisplatin Green tea Inflammation Liver function Oxidative toxic stress |
author_facet |
Nilofar Amidi Shirin Moradkhani Mahsa Sedaghat Nejat Khiripour Amir Larki-Harchegani Nahid Zadkhosh Mahmoud Mirhoseini Akram Ranjbar |
author_sort |
Nilofar Amidi |
title |
Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function |
title_short |
Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function |
title_full |
Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function |
title_fullStr |
Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function |
title_full_unstemmed |
Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function |
title_sort |
effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function |
publisher |
Nikan Research Institute |
series |
Journal of HerbMed Pharmacology |
issn |
2345-5004 |
publishDate |
2016-07-01 |
description |
Introduction: Cisplatin is one of the most potent chemotherapeutic antitumor drugs. Also, oxidative stress has been established to be involved in cisplatin-induced toxicity. Therefore, the present study was undertaken to examine the antioxidant and anti-inflammation potential of green tea hydroalcoholic extract (GTE) against the liver function of cisplatin in male rats. Methods: Adult male Wistar rats (180–250 g) were divided into 4 groups (n = 5) treated as follows: (1) control group (saline solution, 1 ml kg−1 body weight, i.p.), cisplatin group (7 mg kg−1 body weight, i.p.). Animals of Groups III received only green tea extract (30 mg/kg/day, by gavage). Group IV was given green tea extract+ cisplatin once daily for 24 hours. Liver function was evidenced in the cisplatin group by the increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The mechanism of cisplatin induced liver function was considered as being decreased the total antioxidant power (TAP). Systemic inflammation was assessed by tumor necrosis factor-alpha (TNF-α) levels. Results: A decrease in TAP level in cisplatin group was observed compared with control group. GTE administration decreased TNF-α and increased TAP compared to cisplatin group, but showed no significant differences between groups. Conclusion: The results suggested that green tea could ameliorate cisplatin liver function in rats through reduction of oxidative toxic stress and inflammation. |
topic |
Cisplatin Green tea Inflammation Liver function Oxidative toxic stress |
url |
http://herbmedpharmacol.com/PDF/JHP_1012_20160106121949 |
work_keys_str_mv |
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