The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions
Multiple concussions, particularly in contact sports, have been associated with cognitive deficits, psychiatric impairment and neurodegenerative diseases like chronic traumatic encephalopathy. We used volumetric and deformation-based morphometric analyses to test the hypothesis that repeated concuss...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301608 |
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doaj-0587fb5ed94d436388b7ce31bada93b6 |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Karen Misquitta Mahsa Dadar Apameh Tarazi Mohammed W. Hussain Mohammed K. Alatwi Ahmed Ebraheem Namita Multani Mozhgan Khodadadi Ruma Goswami Richard Wennberg Charles Tator Robin Green Brenda Colella Karen Deborah Davis David Mikulis Mark Grinberg Christine Sato Ekaterina Rogaeva D. Louis Collins Maria Carmela Tartaglia |
| spellingShingle |
Karen Misquitta Mahsa Dadar Apameh Tarazi Mohammed W. Hussain Mohammed K. Alatwi Ahmed Ebraheem Namita Multani Mozhgan Khodadadi Ruma Goswami Richard Wennberg Charles Tator Robin Green Brenda Colella Karen Deborah Davis David Mikulis Mark Grinberg Christine Sato Ekaterina Rogaeva D. Louis Collins Maria Carmela Tartaglia The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions NeuroImage: Clinical |
| author_facet |
Karen Misquitta Mahsa Dadar Apameh Tarazi Mohammed W. Hussain Mohammed K. Alatwi Ahmed Ebraheem Namita Multani Mozhgan Khodadadi Ruma Goswami Richard Wennberg Charles Tator Robin Green Brenda Colella Karen Deborah Davis David Mikulis Mark Grinberg Christine Sato Ekaterina Rogaeva D. Louis Collins Maria Carmela Tartaglia |
| author_sort |
Karen Misquitta |
| title |
The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions |
| title_short |
The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions |
| title_full |
The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions |
| title_fullStr |
The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions |
| title_full_unstemmed |
The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions |
| title_sort |
relationship between brain atrophy and cognitive-behavioural symptoms in retired canadian football players with multiple concussions |
| publisher |
Elsevier |
| series |
NeuroImage: Clinical |
| issn |
2213-1582 |
| publishDate |
2018-01-01 |
| description |
Multiple concussions, particularly in contact sports, have been associated with cognitive deficits, psychiatric impairment and neurodegenerative diseases like chronic traumatic encephalopathy. We used volumetric and deformation-based morphometric analyses to test the hypothesis that repeated concussions may be associated with smaller regional brain volumes, poorer cognitive performance and behavioural symptoms among former professional football players compared to healthy controls. This study included fifty-three retired Canadian Football League players, 25 age- and education-matched healthy controls, and controls from the Cambridge Centre for Aging and Neuroscience database for validation. Volumetric analyses revealed greater hippocampal atrophy than expected for age in former athletes with multiple concussions than controls and smaller left hippocampal volume was associated with poorer verbal memory performance in the former athletes. Deformation-based morphometry confirmed smaller bilateral hippocampal volume that was associated with poorer verbal memory performance in athletes. Repeated concussions may lead to greater regional atrophy than expected for age. Keywords: Sport-related concussion, Mild traumatic brain injury, Deformation based morphometry, Aging |
| url |
http://www.sciencedirect.com/science/article/pii/S2213158218301608 |
| work_keys_str_mv |
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doaj-0587fb5ed94d436388b7ce31bada93b62020-11-25T01:22:41ZengElsevierNeuroImage: Clinical2213-15822018-01-0119551558The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussionsKaren Misquitta0Mahsa Dadar1Apameh Tarazi2Mohammed W. Hussain3Mohammed K. Alatwi4Ahmed Ebraheem5Namita Multani6Mozhgan Khodadadi7Ruma Goswami8Richard Wennberg9Charles Tator10Robin Green11Brenda Colella12Karen Deborah Davis13David Mikulis14Mark Grinberg15Christine Sato16Ekaterina Rogaeva17D. Louis Collins18Maria Carmela Tartaglia19Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, 3801 Rue Universite, Montreal, QC H3A 2B4, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada; Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Department of Surgery, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Toronto Rehabilitation Institute, University Health Network, 550 University Ave., Toronto, ON M5G 2A2, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Toronto Rehabilitation Institute, University Health Network, 550 University Ave., Toronto, ON M5G 2A2, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, CanadaCanadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Department of Medical Imaging, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, CanadaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, CanadaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, CanadaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, 3801 Rue Universite, Montreal, QC H3A 2B4, CanadaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada; Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Corresponding author at: Tanz Centre for Research in Neurodegenerative Diseases, Krembil Discovery Tower, 60 Leonard Avenue, 6th floor 6KD-407, Toronto, ON M5T 0S8, Canada.Multiple concussions, particularly in contact sports, have been associated with cognitive deficits, psychiatric impairment and neurodegenerative diseases like chronic traumatic encephalopathy. We used volumetric and deformation-based morphometric analyses to test the hypothesis that repeated concussions may be associated with smaller regional brain volumes, poorer cognitive performance and behavioural symptoms among former professional football players compared to healthy controls. This study included fifty-three retired Canadian Football League players, 25 age- and education-matched healthy controls, and controls from the Cambridge Centre for Aging and Neuroscience database for validation. Volumetric analyses revealed greater hippocampal atrophy than expected for age in former athletes with multiple concussions than controls and smaller left hippocampal volume was associated with poorer verbal memory performance in the former athletes. Deformation-based morphometry confirmed smaller bilateral hippocampal volume that was associated with poorer verbal memory performance in athletes. Repeated concussions may lead to greater regional atrophy than expected for age. Keywords: Sport-related concussion, Mild traumatic brain injury, Deformation based morphometry, Aginghttp://www.sciencedirect.com/science/article/pii/S2213158218301608 |