Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
The Zika virus (ZIKV) epidemic in Brazil occurred in regions where dengue viruses (DENV) are historically endemic. We investigated the differences in adverse pregnancy/infant outcomes in two cohorts comprising 114 pregnant women with PCR-confirmed ZIKV infection in Rio de Janeiro, Southeastern Brazi...
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doaj-05ab3e431bfc46149dda7f952d0a6a5b2021-04-23T23:02:49ZengMDPI AGViruses1999-49152021-04-011373673610.3390/v13050736Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two CohortsLuana Damasceno0Ana Carolina B. Terzian1Trevon Fuller2Cassia F. Estofolete3Adriana Andrade4Erna G. Kroon5Andrea A. Zin6Zilton Vasconcelos7Jose P. Pereira8Márcia C. Castilho9Isa Cristina R. Piaulino10Nikos Vasilakis11Maria E. Moreira12Karin Nielsen-Saines13Flor E. Martinez Espinosa14Maurício L. Nogueira15Patricia Brasil16Acute Febrile Illnesses Laboratory, National Institute of Infectious Diseases, Oswaldo Cruz Foundation (OCRUZ), Rio de Janeiro, RJ 21040-900, BrazilRené Rachou Institute, Oswaldo Cruz Foundation (FIOCRUZ/Minas), Belo Horizonte, MG 30190-002, BrazilAcute Febrile Illnesses Laboratory, National Institute of Infectious Diseases, Oswaldo Cruz Foundation (OCRUZ), Rio de Janeiro, RJ 21040-900, BrazilLaboratory of Virology, School of Medicine (FAMERP), São José do Rio Preto, SP 15090-000, BrazilInstitute of Biological Sciences, Federal University of Minas Gerais (UFMG), Pampulha-Belo Horizonte, MG 31270-901, BrazilInstitute of Biological Sciences, Federal University of Minas Gerais (UFMG), Pampulha-Belo Horizonte, MG 31270-901, BrazilFernandes Figueira Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ 22250-020, BrazilFernandes Figueira Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ 22250-020, BrazilFernandes Figueira Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ 22250-020, BrazilDepartment of Virology, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, AM 69040-000, BrazilPostgraduate Program in Tropical Medicine, Amazonas State University, Manaus, AM 69040-000, BrazilDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USAFernandes Figueira Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ 22250-020, BrazilDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USALaboratory of Territory, Environment, Health, and Sustainability, Leônidas & Maria Deane Institute, Oswaldo Cruz Foundation (FIOCRUZ/Amazonia), Manaus, AM 69057-070, BrazilLaboratory of Virology, School of Medicine (FAMERP), São José do Rio Preto, SP 15090-000, BrazilAcute Febrile Illnesses Laboratory, National Institute of Infectious Diseases, Oswaldo Cruz Foundation (OCRUZ), Rio de Janeiro, RJ 21040-900, BrazilThe Zika virus (ZIKV) epidemic in Brazil occurred in regions where dengue viruses (DENV) are historically endemic. We investigated the differences in adverse pregnancy/infant outcomes in two cohorts comprising 114 pregnant women with PCR-confirmed ZIKV infection in Rio de Janeiro, Southeastern Brazil (<i>n</i> = 50) and Manaus, in the north region of the country (<i>n</i> = 64). Prior exposure to DENV was evaluated through plaque reduction neutralizing antibody assays (PRNT 80) and DENV IgG serologies. Potential associations between pregnancy outcomes and Zika attack rates in the two cities were explored. Overall, 31 women (27%) had adverse pregnancy/infant outcomes, 27 in Rio (54%) and 4 in Manaus (6%), <i>p</i> < 0.001. This included 4 pregnancy losses (13%) and 27 infants with abnormalities at birth (24%). A total of 93 women (82%) had evidence of prior DENV exposure, 45 in Rio (90%) and 48 in Manaus (75%). Zika attack rates differed; the rate in Rio was 10.28 cases/10,000 and in Manaus, 0.6 cases/10,000, <i>p</i> < 0.001. Only Zika attack rates (Odds Ratio: 17.6, 95% Confidence Interval 5.6–55.9, <i>p</i> < 0.001) and infection in the first trimester of pregnancy (OR: 4.26, 95% CI 1.4–12.9, <i>p</i> = 0.011) were associated with adverse pregnancy and infant outcomes. Pre-existing immunity to DENV was not associated with outcomes (normal or abnormal) in patients with ZIKV infection during pregnancy.https://www.mdpi.com/1999-4915/13/5/736Zikapregnancyobstetricsarbovirusesdengue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luana Damasceno Ana Carolina B. Terzian Trevon Fuller Cassia F. Estofolete Adriana Andrade Erna G. Kroon Andrea A. Zin Zilton Vasconcelos Jose P. Pereira Márcia C. Castilho Isa Cristina R. Piaulino Nikos Vasilakis Maria E. Moreira Karin Nielsen-Saines Flor E. Martinez Espinosa Maurício L. Nogueira Patricia Brasil |
spellingShingle |
Luana Damasceno Ana Carolina B. Terzian Trevon Fuller Cassia F. Estofolete Adriana Andrade Erna G. Kroon Andrea A. Zin Zilton Vasconcelos Jose P. Pereira Márcia C. Castilho Isa Cristina R. Piaulino Nikos Vasilakis Maria E. Moreira Karin Nielsen-Saines Flor E. Martinez Espinosa Maurício L. Nogueira Patricia Brasil Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts Viruses Zika pregnancy obstetrics arboviruses dengue |
author_facet |
Luana Damasceno Ana Carolina B. Terzian Trevon Fuller Cassia F. Estofolete Adriana Andrade Erna G. Kroon Andrea A. Zin Zilton Vasconcelos Jose P. Pereira Márcia C. Castilho Isa Cristina R. Piaulino Nikos Vasilakis Maria E. Moreira Karin Nielsen-Saines Flor E. Martinez Espinosa Maurício L. Nogueira Patricia Brasil |
author_sort |
Luana Damasceno |
title |
Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts |
title_short |
Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts |
title_full |
Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts |
title_fullStr |
Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts |
title_full_unstemmed |
Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts |
title_sort |
why did zikv perinatal outcomes differ in distinct regions of brazil? an exploratory study of two cohorts |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-04-01 |
description |
The Zika virus (ZIKV) epidemic in Brazil occurred in regions where dengue viruses (DENV) are historically endemic. We investigated the differences in adverse pregnancy/infant outcomes in two cohorts comprising 114 pregnant women with PCR-confirmed ZIKV infection in Rio de Janeiro, Southeastern Brazil (<i>n</i> = 50) and Manaus, in the north region of the country (<i>n</i> = 64). Prior exposure to DENV was evaluated through plaque reduction neutralizing antibody assays (PRNT 80) and DENV IgG serologies. Potential associations between pregnancy outcomes and Zika attack rates in the two cities were explored. Overall, 31 women (27%) had adverse pregnancy/infant outcomes, 27 in Rio (54%) and 4 in Manaus (6%), <i>p</i> < 0.001. This included 4 pregnancy losses (13%) and 27 infants with abnormalities at birth (24%). A total of 93 women (82%) had evidence of prior DENV exposure, 45 in Rio (90%) and 48 in Manaus (75%). Zika attack rates differed; the rate in Rio was 10.28 cases/10,000 and in Manaus, 0.6 cases/10,000, <i>p</i> < 0.001. Only Zika attack rates (Odds Ratio: 17.6, 95% Confidence Interval 5.6–55.9, <i>p</i> < 0.001) and infection in the first trimester of pregnancy (OR: 4.26, 95% CI 1.4–12.9, <i>p</i> = 0.011) were associated with adverse pregnancy and infant outcomes. Pre-existing immunity to DENV was not associated with outcomes (normal or abnormal) in patients with ZIKV infection during pregnancy. |
topic |
Zika pregnancy obstetrics arboviruses dengue |
url |
https://www.mdpi.com/1999-4915/13/5/736 |
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