Omega-3 polyunsaturated fatty acids in cardiology
Long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFA): eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - have some important biological effects that can be used in cardiology. Long-chain omega-3 PUFA intake, in the dose of 3-4 g/d and more, decrease hypertriglyceridemia, thrombogenesi...
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«SILICEA-POLIGRAF» LLC
2005-08-01
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Online Access: | https://cardiovascular.elpub.ru/jour/article/view/994 |
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doaj-05ce025dee2d484abf6307bfc4dcae232021-07-28T13:50:41Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252005-08-0144101107708Omega-3 polyunsaturated fatty acids in cardiologyN. V. Perova0State Research Center for Preventive Medicine, Ministry of Health of the Russian Federation, MoscowLong-chain omega-3 polyunsaturated fatty acids (ω-3 PUFA): eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - have some important biological effects that can be used in cardiology. Long-chain omega-3 PUFA intake, in the dose of 3-4 g/d and more, decrease hypertriglyceridemia, thrombogenesis, inflammatory and immune processes, and vascular tonus. Free EPA and DHA act as structural components of cell membranes; they modify –inhibit trans-membrane ion channels; demonstrate antiarrhythmic effects; increase heart rate variability. In GISSI-Prevenzione study, among patients taking omega-3 PUFA, the incidence of combined end-point (total mortality, nonfatal myocardial infarction (MI), and stroke (S)) was lower than that in placebo group, by 15-16% (Р=0.02). Cardiovascular death risk, plus nonfatal MI and S risk, was also lower, comparing to placebo group (-20-21%; Р=0.006). The risk reduction was maximal (-45%; Р=0.0006) for sudden death; its risk was decreased as early as after 4 months of treatment.https://cardiovascular.elpub.ru/jour/article/view/994omega-3 polyunsaturated fatty acidseicosapentaenoic aciddocosahexaenoic acidomacor |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
N. V. Perova |
spellingShingle |
N. V. Perova Omega-3 polyunsaturated fatty acids in cardiology Кардиоваскулярная терапия и профилактика omega-3 polyunsaturated fatty acids eicosapentaenoic acid docosahexaenoic acid omacor |
author_facet |
N. V. Perova |
author_sort |
N. V. Perova |
title |
Omega-3 polyunsaturated fatty acids in cardiology |
title_short |
Omega-3 polyunsaturated fatty acids in cardiology |
title_full |
Omega-3 polyunsaturated fatty acids in cardiology |
title_fullStr |
Omega-3 polyunsaturated fatty acids in cardiology |
title_full_unstemmed |
Omega-3 polyunsaturated fatty acids in cardiology |
title_sort |
omega-3 polyunsaturated fatty acids in cardiology |
publisher |
«SILICEA-POLIGRAF» LLC |
series |
Кардиоваскулярная терапия и профилактика |
issn |
1728-8800 2619-0125 |
publishDate |
2005-08-01 |
description |
Long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFA): eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - have some important biological effects that can be used in cardiology. Long-chain omega-3 PUFA intake, in the dose of 3-4 g/d and more, decrease hypertriglyceridemia, thrombogenesis, inflammatory and immune processes, and vascular tonus. Free EPA and DHA act as structural components of cell membranes; they modify –inhibit trans-membrane ion channels; demonstrate antiarrhythmic effects; increase heart rate variability. In GISSI-Prevenzione study, among patients taking omega-3 PUFA, the incidence of combined end-point (total mortality, nonfatal myocardial infarction (MI), and stroke (S)) was lower than that in placebo group, by 15-16% (Р=0.02). Cardiovascular death risk, plus nonfatal MI and S risk, was also lower, comparing to placebo group (-20-21%; Р=0.006). The risk reduction was maximal (-45%; Р=0.0006) for sudden death; its risk was decreased as early as after 4 months of treatment. |
topic |
omega-3 polyunsaturated fatty acids eicosapentaenoic acid docosahexaenoic acid omacor |
url |
https://cardiovascular.elpub.ru/jour/article/view/994 |
work_keys_str_mv |
AT nvperova omega3polyunsaturatedfattyacidsincardiology |
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1721271416100225024 |