Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino...

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Bibliographic Details
Main Authors: Patrice Vanelle, Thierry Terme, Manon Roche
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
TDAE
propargylic alcohol
organic reducing agent
aromatic aldehyde
Online Access:http://www.mdpi.com/1420-3049/18/2/1540

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