Hypothalamic leptin action is mediated by histone deacetylase 5

Hypothalamic leptin action is mediated by histone deacetylase 5

Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating S...

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Main Authors: Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10782
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spelling doaj-05d180e6a43443a4a0aaf1a16b919fe22021-05-11T10:46:19ZengNature Publishing GroupNature Communications2041-17232016-02-017111210.1038/ncomms10782Hypothalamic leptin action is mediated by histone deacetylase 5Dhiraj G. Kabra0Katrin Pfuhlmann1Cristina García-Cáceres2Sonja C. Schriever3Veronica Casquero García4Adam Fiseha Kebede5Esther Fuente-Martin6Chitrang Trivedi7Kristy Heppner8N. Henriette Uhlenhaut9Beata Legutko10Uma D. Kabra11Yuanqing Gao12Chun-Xia Yi13Carmelo Quarta14Christoffer Clemmensen15Brian Finan16Timo D. Müller17Carola W. Meyer18Marcelo Paez-Pereda19Kerstin Stemmer20Stephen C. Woods21Diego Perez-Tilve22Robert Schneider23Eric N. Olson24Matthias H. Tschöp25Paul T. Pfluger26Helmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de StrasbourgHelmholtz Diabetes Center, Helmholtz Zentrum MünchenDepartment of Pharmacology & Toxicology, Zydus Research Centre, Cadila Healthcare LimitedDivision of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of CincinnatiHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenMax Planck Institute of PsychiatryHelmholtz Diabetes Center, Helmholtz Zentrum MünchenDivision of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of CincinnatiDivision of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of CincinnatiInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de StrasbourgDepartment of Molecular Biology, UT Southwestern Medical CenterHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHelmholtz Diabetes Center, Helmholtz Zentrum MünchenHistone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.https://doi.org/10.1038/ncomms10782
collection DOAJ
language English
format Article
sources DOAJ
author Dhiraj G. Kabra
Katrin Pfuhlmann
Cristina García-Cáceres
Sonja C. Schriever
Veronica Casquero García
Adam Fiseha Kebede
Esther Fuente-Martin
Chitrang Trivedi
Kristy Heppner
N. Henriette Uhlenhaut
Beata Legutko
Uma D. Kabra
Yuanqing Gao
Chun-Xia Yi
Carmelo Quarta
Christoffer Clemmensen
Brian Finan
Timo D. Müller
Carola W. Meyer
Marcelo Paez-Pereda
Kerstin Stemmer
Stephen C. Woods
Diego Perez-Tilve
Robert Schneider
Eric N. Olson
Matthias H. Tschöp
Paul T. Pfluger
spellingShingle Dhiraj G. Kabra
Katrin Pfuhlmann
Cristina García-Cáceres
Sonja C. Schriever
Veronica Casquero García
Adam Fiseha Kebede
Esther Fuente-Martin
Chitrang Trivedi
Kristy Heppner
N. Henriette Uhlenhaut
Beata Legutko
Uma D. Kabra
Yuanqing Gao
Chun-Xia Yi
Carmelo Quarta
Christoffer Clemmensen
Brian Finan
Timo D. Müller
Carola W. Meyer
Marcelo Paez-Pereda
Kerstin Stemmer
Stephen C. Woods
Diego Perez-Tilve
Robert Schneider
Eric N. Olson
Matthias H. Tschöp
Paul T. Pfluger
Hypothalamic leptin action is mediated by histone deacetylase 5
Nature Communications
author_facet Dhiraj G. Kabra
Katrin Pfuhlmann
Cristina García-Cáceres
Sonja C. Schriever
Veronica Casquero García
Adam Fiseha Kebede
Esther Fuente-Martin
Chitrang Trivedi
Kristy Heppner
N. Henriette Uhlenhaut
Beata Legutko
Uma D. Kabra
Yuanqing Gao
Chun-Xia Yi
Carmelo Quarta
Christoffer Clemmensen
Brian Finan
Timo D. Müller
Carola W. Meyer
Marcelo Paez-Pereda
Kerstin Stemmer
Stephen C. Woods
Diego Perez-Tilve
Robert Schneider
Eric N. Olson
Matthias H. Tschöp
Paul T. Pfluger
author_sort Dhiraj G. Kabra
title Hypothalamic leptin action is mediated by histone deacetylase 5
title_short Hypothalamic leptin action is mediated by histone deacetylase 5
title_full Hypothalamic leptin action is mediated by histone deacetylase 5
title_fullStr Hypothalamic leptin action is mediated by histone deacetylase 5
title_full_unstemmed Hypothalamic leptin action is mediated by histone deacetylase 5
title_sort hypothalamic leptin action is mediated by histone deacetylase 5
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.
url https://doi.org/10.1038/ncomms10782
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