Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling
Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endoso...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12221-6 |
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doaj-05e31276e2a744fdb7699f4e17f5be4d2021-05-11T11:44:48ZengNature Publishing GroupNature Communications2041-17232019-09-0110111710.1038/s41467-019-12221-6Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recyclingAmika Singla0Alina Fedoseienko1Sai S. P. Giridharan2Brittany L. Overlee3Adam Lopez4Da Jia5Jie Song6Kayci Huff-Hardy7Lois Weisman8Ezra Burstein9Daniel D. Billadeau10Department of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical CenterDivision of Oncology Research and Department of Biochemistry and Molecular Biology, College of Medicine, Mayo ClinicLife Sciences Institute, University of MichiganDivision of Oncology Research and Department of Biochemistry and Molecular Biology, College of Medicine, Mayo ClinicDepartment of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical CenterKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, Division of Neurology, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan UniversityDepartment of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical CenterDepartment of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical CenterLife Sciences Institute, University of MichiganDepartment of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical CenterDivision of Oncology Research and Department of Biochemistry and Molecular Biology, College of Medicine, Mayo ClinicRecycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endosomal membranes.https://doi.org/10.1038/s41467-019-12221-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Amika Singla Alina Fedoseienko Sai S. P. Giridharan Brittany L. Overlee Adam Lopez Da Jia Jie Song Kayci Huff-Hardy Lois Weisman Ezra Burstein Daniel D. Billadeau |
| spellingShingle |
Amika Singla Alina Fedoseienko Sai S. P. Giridharan Brittany L. Overlee Adam Lopez Da Jia Jie Song Kayci Huff-Hardy Lois Weisman Ezra Burstein Daniel D. Billadeau Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling Nature Communications |
| author_facet |
Amika Singla Alina Fedoseienko Sai S. P. Giridharan Brittany L. Overlee Adam Lopez Da Jia Jie Song Kayci Huff-Hardy Lois Weisman Ezra Burstein Daniel D. Billadeau |
| author_sort |
Amika Singla |
| title |
Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling |
| title_short |
Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling |
| title_full |
Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling |
| title_fullStr |
Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling |
| title_full_unstemmed |
Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling |
| title_sort |
endosomal pi(3)p regulation by the commd/ccdc22/ccdc93 (ccc) complex controls membrane protein recycling |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-09-01 |
| description |
Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endosomal membranes. |
| url |
https://doi.org/10.1038/s41467-019-12221-6 |
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