Transplantation Induces Profound Changes in the Transcriptional Asset of Hematopoietic Stem Cells: Identification of Specific Signatures Using Machine Learning Techniques

Transplantation Induces Profound Changes in the Transcriptional Asset of Hematopoietic Stem Cells: Identification of Specific Signatures Using Machine Learning Techniques

During the phase of proliferation needed for hematopoietic reconstitution following transplantation, hematopoietic stem/progenitor cells (HSPC) must express genes involved in stem cell self-renewal. We investigated the expression of genes relevant for self-renewal and expansion of HSPC (operationall...

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Bibliographic Details
Main Authors: Daniela Cilloni, Jessica Petiti, Valentina Campia, Marina Podestà, Margherita Squillario, Nuria Montserrat, Alice Bertaina, Federica Sabatini, Sonia Carturan, Massimo Berger, Francesco Saglio, Giuseppe Bandini, Francesca Bonifazi, Franca Fagioli, Lorenzo Moretta, Giuseppe Saglio, Alessandro Verri, Annalisa Barla, Franco Locatelli, Francesco Frassoni
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Journal of Clinical Medicine
Subjects:
hematopoietic stem/progenitor cell
cord blood
stem cell transplantation
Online Access:https://www.mdpi.com/2077-0383/9/6/1670

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