Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway
The functional alteration of nucleus pulposus cells (NPCs) exerts a crucial role in the occurrence and progression of intervertebral disk degeneration (IDD). Circular RNAs and microRNAs (miRs) are critical regulators of NPC metabolic processes such as growth and apoptosis. In this study, bioinformat...
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2021-06-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.656759/full |
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doaj-05edd8ac6e924b7bac0d2a5f53b0403c2021-06-11T10:17:28ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-06-011210.3389/fgene.2021.656759656759Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 PathwayYongjin Li0Yongjin Li1Yongjin Li2Xuke Wang3Xuke Wang4Haiwei Xu5Guowang Li6Guowang Li7Guowang Li8Zhenxin Huo9Zhenxin Huo10Zhenxin Huo11Lilong Du12Lilong Du13Lilong Du14Kaihui Zhang15Kaihui Zhang16Kaihui Zhang17Li Shen18Li Shen19Li Shen20Hao Li21Hao Li22Hao Li23Baoshan Xu24Baoshan Xu25Baoshan Xu26Department of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Luoyang Orthopedic- Traumatological Hospital, Luoyang, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaTianjin Hospital, Orthopedic Research Institute, Tianjin, ChinaThe functional alteration of nucleus pulposus cells (NPCs) exerts a crucial role in the occurrence and progression of intervertebral disk degeneration (IDD). Circular RNAs and microRNAs (miRs) are critical regulators of NPC metabolic processes such as growth and apoptosis. In this study, bioinformatics tools, encompassing Gene Ontology pathway and Venn diagrams analysis, and protein–protein interaction (PPI) network construction were used to identify functional molecules related to IDD. PPI network unveiled that ESR1 was one of the most critical genes in IDD. Then, a key IDD-related circ_0040039-miR-874-3p-ESR1 interaction network was predicted and constructed. Circ_0040039 promoted miR-874-3p and repressed ESR1 expression, and miR-874-3p repressed ESR1 expression in NPCs, suggesting ESR1 might be a direct target of miR-874-3p. Functionally, circ_0040039 could enhance NPC apoptosis and inhibit NPC growth, revealing that circ_0040039 might aggravate IDD by stabilizing miR-874-3p and further upregulating the miR-874-3p-ESR1 pathway. This signaling pathway might provide a novel therapeutic strategy and targets for the diagnosis and therapy of IDD-related diseases.https://www.frontiersin.org/articles/10.3389/fgene.2021.656759/fullcircular RNAESR1apoptosisintervertebral disk degenerationmiR-874-3p |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yongjin Li Yongjin Li Yongjin Li Xuke Wang Xuke Wang Haiwei Xu Guowang Li Guowang Li Guowang Li Zhenxin Huo Zhenxin Huo Zhenxin Huo Lilong Du Lilong Du Lilong Du Kaihui Zhang Kaihui Zhang Kaihui Zhang Li Shen Li Shen Li Shen Hao Li Hao Li Hao Li Baoshan Xu Baoshan Xu Baoshan Xu |
spellingShingle |
Yongjin Li Yongjin Li Yongjin Li Xuke Wang Xuke Wang Haiwei Xu Guowang Li Guowang Li Guowang Li Zhenxin Huo Zhenxin Huo Zhenxin Huo Lilong Du Lilong Du Lilong Du Kaihui Zhang Kaihui Zhang Kaihui Zhang Li Shen Li Shen Li Shen Hao Li Hao Li Hao Li Baoshan Xu Baoshan Xu Baoshan Xu Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway Frontiers in Genetics circular RNA ESR1 apoptosis intervertebral disk degeneration miR-874-3p |
author_facet |
Yongjin Li Yongjin Li Yongjin Li Xuke Wang Xuke Wang Haiwei Xu Guowang Li Guowang Li Guowang Li Zhenxin Huo Zhenxin Huo Zhenxin Huo Lilong Du Lilong Du Lilong Du Kaihui Zhang Kaihui Zhang Kaihui Zhang Li Shen Li Shen Li Shen Hao Li Hao Li Hao Li Baoshan Xu Baoshan Xu Baoshan Xu |
author_sort |
Yongjin Li |
title |
Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway |
title_short |
Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway |
title_full |
Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway |
title_fullStr |
Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway |
title_full_unstemmed |
Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway |
title_sort |
circ_0040039 may aggravate intervertebral disk degeneration by regulating the mir-874-3p-esr1 pathway |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2021-06-01 |
description |
The functional alteration of nucleus pulposus cells (NPCs) exerts a crucial role in the occurrence and progression of intervertebral disk degeneration (IDD). Circular RNAs and microRNAs (miRs) are critical regulators of NPC metabolic processes such as growth and apoptosis. In this study, bioinformatics tools, encompassing Gene Ontology pathway and Venn diagrams analysis, and protein–protein interaction (PPI) network construction were used to identify functional molecules related to IDD. PPI network unveiled that ESR1 was one of the most critical genes in IDD. Then, a key IDD-related circ_0040039-miR-874-3p-ESR1 interaction network was predicted and constructed. Circ_0040039 promoted miR-874-3p and repressed ESR1 expression, and miR-874-3p repressed ESR1 expression in NPCs, suggesting ESR1 might be a direct target of miR-874-3p. Functionally, circ_0040039 could enhance NPC apoptosis and inhibit NPC growth, revealing that circ_0040039 might aggravate IDD by stabilizing miR-874-3p and further upregulating the miR-874-3p-ESR1 pathway. This signaling pathway might provide a novel therapeutic strategy and targets for the diagnosis and therapy of IDD-related diseases. |
topic |
circular RNA ESR1 apoptosis intervertebral disk degeneration miR-874-3p |
url |
https://www.frontiersin.org/articles/10.3389/fgene.2021.656759/full |
work_keys_str_mv |
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