Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.

The body mass index (BMI) standard deviation score (SDS) may not adequately reflect changes in fat mass during childhood obesity treatment. This study aimed to investigate associations between BMI SDS, body composition, and fasting plasma lipid concentrations at baseline and during childhood obesity...

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Main Authors: Tenna Ruest Haarmark Nielsen, Cilius Esmann Fonvig, Maria Dahl, Pernille Maria Mollerup, Ulrik Lausten-Thomsen, Oluf Pedersen, Torben Hansen, Jens-Christian Holm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5812566?pdf=render
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spelling doaj-05ee7f73159243c5afeefcf3bebcfdde2020-11-25T01:10:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01132e019057610.1371/journal.pone.0190576Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.Tenna Ruest Haarmark NielsenCilius Esmann FonvigMaria DahlPernille Maria MollerupUlrik Lausten-ThomsenOluf PedersenTorben HansenJens-Christian HolmThe body mass index (BMI) standard deviation score (SDS) may not adequately reflect changes in fat mass during childhood obesity treatment. This study aimed to investigate associations between BMI SDS, body composition, and fasting plasma lipid concentrations at baseline and during childhood obesity treatment.876 children and adolescents (498 girls) with overweight/obesity, median age 11.2 years (range 1.6-21.7), and median BMI SDS 2.8 (range 1.3-5.7) were enrolled in a multidisciplinary outpatient treatment program and followed for a median of 1.8 years (range 0.4-7.4). Height and weight, body composition measured by dual-energy X-ray absorptiometry, and fasting plasma lipid concentrations were assessed at baseline and at follow-up. Lipid concentrations (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), non-HDL, and triglycerides (TG)) were available in 469 individuals (264 girls). Linear regressions were performed to investigate the associations between BMI SDS, body composition indices, and lipid concentrations.At baseline, BMI SDS was negatively associated with concentrations of HDL (p = 6.7*10-4) and positively with TG (p = 9.7*10-6). Reductions in BMI SDS were associated with reductions in total body fat percentage (p<2*10-16) and percent truncal body fat (p<2*10-16). Furthermore, reductions in BMI SDS were associated with improvements in concentrations of TC, LDL, HDL, non-HDL, LDL/HDL-ratio, and TG (all p <0.0001). Changes in body fat percentage seemed to mediate the changes in plasma concentrations of TC, LDL, and non-HDL, but could not alone explain the changes in HDL, LDL/HDL-ratio or TG. Among 81 individuals with available lipid concentrations, who increased their BMI SDS, 61% improved their body composition, and 80% improved their lipid concentrations.Reductions in the degree of obesity during multidisciplinary childhood obesity treatment are accompanied by improvements in body composition and fasting plasma lipid concentrations. Even in individuals increasing their BMI SDS, body composition and lipid concentrations may improve.http://europepmc.org/articles/PMC5812566?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Tenna Ruest Haarmark Nielsen
Cilius Esmann Fonvig
Maria Dahl
Pernille Maria Mollerup
Ulrik Lausten-Thomsen
Oluf Pedersen
Torben Hansen
Jens-Christian Holm
spellingShingle Tenna Ruest Haarmark Nielsen
Cilius Esmann Fonvig
Maria Dahl
Pernille Maria Mollerup
Ulrik Lausten-Thomsen
Oluf Pedersen
Torben Hansen
Jens-Christian Holm
Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.
PLoS ONE
author_facet Tenna Ruest Haarmark Nielsen
Cilius Esmann Fonvig
Maria Dahl
Pernille Maria Mollerup
Ulrik Lausten-Thomsen
Oluf Pedersen
Torben Hansen
Jens-Christian Holm
author_sort Tenna Ruest Haarmark Nielsen
title Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.
title_short Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.
title_full Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.
title_fullStr Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.
title_full_unstemmed Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.
title_sort childhood obesity treatment; effects on bmi sds, body composition, and fasting plasma lipid concentrations.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description The body mass index (BMI) standard deviation score (SDS) may not adequately reflect changes in fat mass during childhood obesity treatment. This study aimed to investigate associations between BMI SDS, body composition, and fasting plasma lipid concentrations at baseline and during childhood obesity treatment.876 children and adolescents (498 girls) with overweight/obesity, median age 11.2 years (range 1.6-21.7), and median BMI SDS 2.8 (range 1.3-5.7) were enrolled in a multidisciplinary outpatient treatment program and followed for a median of 1.8 years (range 0.4-7.4). Height and weight, body composition measured by dual-energy X-ray absorptiometry, and fasting plasma lipid concentrations were assessed at baseline and at follow-up. Lipid concentrations (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), non-HDL, and triglycerides (TG)) were available in 469 individuals (264 girls). Linear regressions were performed to investigate the associations between BMI SDS, body composition indices, and lipid concentrations.At baseline, BMI SDS was negatively associated with concentrations of HDL (p = 6.7*10-4) and positively with TG (p = 9.7*10-6). Reductions in BMI SDS were associated with reductions in total body fat percentage (p<2*10-16) and percent truncal body fat (p<2*10-16). Furthermore, reductions in BMI SDS were associated with improvements in concentrations of TC, LDL, HDL, non-HDL, LDL/HDL-ratio, and TG (all p <0.0001). Changes in body fat percentage seemed to mediate the changes in plasma concentrations of TC, LDL, and non-HDL, but could not alone explain the changes in HDL, LDL/HDL-ratio or TG. Among 81 individuals with available lipid concentrations, who increased their BMI SDS, 61% improved their body composition, and 80% improved their lipid concentrations.Reductions in the degree of obesity during multidisciplinary childhood obesity treatment are accompanied by improvements in body composition and fasting plasma lipid concentrations. Even in individuals increasing their BMI SDS, body composition and lipid concentrations may improve.
url http://europepmc.org/articles/PMC5812566?pdf=render
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