Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine
We explored the relationship between obstructive sleep apnea (OSA) patients’ anthropometric measures and the CPAP treatment response. To that end, we processed three non-overlapping cohorts (<inline-formula><math display="inline"><semantics><msub><mi>D</mi&...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | Diagnostics |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4418/11/1/86 |
id |
doaj-05fc569bccd2408db8673e425e553c17 |
---|---|
record_format |
Article |
spelling |
doaj-05fc569bccd2408db8673e425e553c172021-01-08T00:01:55ZengMDPI AGDiagnostics2075-44182021-01-0111868610.3390/diagnostics11010086Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network MedicineStefan Mihaicuta0Lucreţia Udrescu1Mihai Udrescu2Izabella-Anita Toth3Alexandru Topîrceanu4Roxana Pleavă5Carmen Ardelean6Department of Pulmonology, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 300041 Timişoara, RomaniaDepartment I—Drug Analysis, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, RomaniaDepartment of Computer and Information Technology, University Politehnica of Timişoara, 2 Vasile Pârvan Blvd., 300223 Timişoara, RomaniaDepartment of Pulmonology, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 300041 Timişoara, RomaniaDepartment of Computer and Information Technology, University Politehnica of Timişoara, 2 Vasile Pârvan Blvd., 300223 Timişoara, RomaniaDepartment of Cardiology, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 300041 Timişoara, RomaniaCardioPrevent Foundation, 3 Calea Dorobanţilor, 300134 Timişoara, RomaniaWe explored the relationship between obstructive sleep apnea (OSA) patients’ anthropometric measures and the CPAP treatment response. To that end, we processed three non-overlapping cohorts (<inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula>, <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>2</mn></msub></semantics></math></inline-formula>, <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>3</mn></msub></semantics></math></inline-formula>) with 1046 patients from four sleep laboratories in Western Romania, including 145 subjects (<inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula>) with one-night CPAP therapy. Using <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula> data, we created a CPAP-response network of patients, and found neck circumference (NC) as the most significant qualitative indicator for apnea–hypopnea index (AHI) improvement. We also investigated a quantitative NC cutoff value for OSA screening on cohorts <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>2</mn></msub></semantics></math></inline-formula> (OSA-diagnosed) and <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>3</mn></msub></semantics></math></inline-formula> (control), using the area under the curve. As such, we confirmed the correlation between NC and AHI (<inline-formula><math display="inline"><semantics><mrow><mi>ρ</mi><mo>=</mo><mn>0.35</mn></mrow></semantics></math></inline-formula>, <inline-formula><math display="inline"><semantics><mrow><mi>p</mi><mo><</mo><mn>0.001</mn></mrow></semantics></math></inline-formula>) and showed that 71% of diagnosed male subjects had bigger NC values than subjects with no OSA (area under the curve is 0.71, with 95% CI 0.63–0.79, <inline-formula><math display="inline"><semantics><mrow><mi>p</mi><mo><</mo><mn>0.001</mn></mrow></semantics></math></inline-formula>); the optimal NC cutoff is 41 cm, with a sensitivity of 0.8099, a specificity of 0.5185, positive predicted value (PPV) = 0.9588, negative predicted value (NPV) = 0.1647, and positive likelihood ratio (LR+) = 1.68. Our NC <inline-formula><math display="inline"><semantics><mrow><mo>=</mo><mn>41</mn></mrow></semantics></math></inline-formula> cm threshold classified the <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula> patients’ CPAP responses—measured as the difference in AHI prior to and after the one-night use of CPAP—with a sensitivity of 0.913 and a specificity of 0.859.https://www.mdpi.com/2075-4418/11/1/86network medicineobstructive sleep apnea syndromeCPAP treatment responseanthropometric measures |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefan Mihaicuta Lucreţia Udrescu Mihai Udrescu Izabella-Anita Toth Alexandru Topîrceanu Roxana Pleavă Carmen Ardelean |
spellingShingle |
Stefan Mihaicuta Lucreţia Udrescu Mihai Udrescu Izabella-Anita Toth Alexandru Topîrceanu Roxana Pleavă Carmen Ardelean Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine Diagnostics network medicine obstructive sleep apnea syndrome CPAP treatment response anthropometric measures |
author_facet |
Stefan Mihaicuta Lucreţia Udrescu Mihai Udrescu Izabella-Anita Toth Alexandru Topîrceanu Roxana Pleavă Carmen Ardelean |
author_sort |
Stefan Mihaicuta |
title |
Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine |
title_short |
Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine |
title_full |
Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine |
title_fullStr |
Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine |
title_full_unstemmed |
Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine |
title_sort |
analyzing neck circumference as an indicator of cpap treatment response in obstructive sleep apnea with network medicine |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-01-01 |
description |
We explored the relationship between obstructive sleep apnea (OSA) patients’ anthropometric measures and the CPAP treatment response. To that end, we processed three non-overlapping cohorts (<inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula>, <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>2</mn></msub></semantics></math></inline-formula>, <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>3</mn></msub></semantics></math></inline-formula>) with 1046 patients from four sleep laboratories in Western Romania, including 145 subjects (<inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula>) with one-night CPAP therapy. Using <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula> data, we created a CPAP-response network of patients, and found neck circumference (NC) as the most significant qualitative indicator for apnea–hypopnea index (AHI) improvement. We also investigated a quantitative NC cutoff value for OSA screening on cohorts <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>2</mn></msub></semantics></math></inline-formula> (OSA-diagnosed) and <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>3</mn></msub></semantics></math></inline-formula> (control), using the area under the curve. As such, we confirmed the correlation between NC and AHI (<inline-formula><math display="inline"><semantics><mrow><mi>ρ</mi><mo>=</mo><mn>0.35</mn></mrow></semantics></math></inline-formula>, <inline-formula><math display="inline"><semantics><mrow><mi>p</mi><mo><</mo><mn>0.001</mn></mrow></semantics></math></inline-formula>) and showed that 71% of diagnosed male subjects had bigger NC values than subjects with no OSA (area under the curve is 0.71, with 95% CI 0.63–0.79, <inline-formula><math display="inline"><semantics><mrow><mi>p</mi><mo><</mo><mn>0.001</mn></mrow></semantics></math></inline-formula>); the optimal NC cutoff is 41 cm, with a sensitivity of 0.8099, a specificity of 0.5185, positive predicted value (PPV) = 0.9588, negative predicted value (NPV) = 0.1647, and positive likelihood ratio (LR+) = 1.68. Our NC <inline-formula><math display="inline"><semantics><mrow><mo>=</mo><mn>41</mn></mrow></semantics></math></inline-formula> cm threshold classified the <inline-formula><math display="inline"><semantics><msub><mi>D</mi><mn>1</mn></msub></semantics></math></inline-formula> patients’ CPAP responses—measured as the difference in AHI prior to and after the one-night use of CPAP—with a sensitivity of 0.913 and a specificity of 0.859. |
topic |
network medicine obstructive sleep apnea syndrome CPAP treatment response anthropometric measures |
url |
https://www.mdpi.com/2075-4418/11/1/86 |
work_keys_str_mv |
AT stefanmihaicuta analyzingneckcircumferenceasanindicatorofcpaptreatmentresponseinobstructivesleepapneawithnetworkmedicine AT lucretiaudrescu analyzingneckcircumferenceasanindicatorofcpaptreatmentresponseinobstructivesleepapneawithnetworkmedicine AT mihaiudrescu analyzingneckcircumferenceasanindicatorofcpaptreatmentresponseinobstructivesleepapneawithnetworkmedicine AT izabellaanitatoth analyzingneckcircumferenceasanindicatorofcpaptreatmentresponseinobstructivesleepapneawithnetworkmedicine AT alexandrutopirceanu analyzingneckcircumferenceasanindicatorofcpaptreatmentresponseinobstructivesleepapneawithnetworkmedicine AT roxanapleava analyzingneckcircumferenceasanindicatorofcpaptreatmentresponseinobstructivesleepapneawithnetworkmedicine AT carmenardelean analyzingneckcircumferenceasanindicatorofcpaptreatmentresponseinobstructivesleepapneawithnetworkmedicine |
_version_ |
1724345791656493056 |