Two Secreted Proteoglycans, Activators of Urothelial Cell–Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression

Two Secreted Proteoglycans, Activators of Urothelial Cell–Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression

Osteomodulin (OMD) and proline/arginine-rich end leucine repeat protein (PRELP) are secreted extracellular matrix proteins belonging to the small leucine-rich proteoglycans family. We found that OMD and PRELP were specifically expressed in umbrella cells in bladder epithelia, and their expression le...

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Bibliographic Details
Main Authors: Vasiliki Papadaki, Ken Asada, Julie K. Watson, Toshiya Tamura, Alex Leung, Jack Hopkins, Margaret Dellett, Noriaki Sasai, Hongorzul Davaapil, Serena Nik-Zainal, Rebecca Longbottom, Makoto Nakakido, Ryo Torii, Abhi Veerakumarasivam, Syuzo Kaneko, Mandeep S. Sagoo, Gillian Murphy, Akihisa Mitani, Kohei Tsumoto, John D. Kelly, Ryuji Hamamoto, Shin-ichi Ohnuma
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
OMD
PRELP
tumor suppression gene
bladder cancer initiation
tight junction
partial EMT
Online Access:https://www.mdpi.com/2072-6694/12/11/3362

Internet

https://www.mdpi.com/2072-6694/12/11/3362

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