A new model for pore formation by cholesterol-dependent cytolysins.
Cholesterol Dependent Cytolysins (CDCs) are important bacterial virulence factors that form large (200-300 Å) membrane embedded pores in target cells. Currently, insights from X-ray crystallography, biophysical and single particle cryo-Electron Microscopy (cryo-EM) experiments suggest that soluble m...
Main Authors: | Cyril F Reboul, James C Whisstock, Michelle A Dunstone |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-08-01
|
Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC4140638?pdf=render |
Similar Items
-
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin
by: Carl Leung, et al.
Published: (2014-12-01) -
Correction: Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin
by: Carl Leung, et al.
Published: (2015-02-01) -
Studies of the cholesterol-dependent cytolysins
by: Cowan, Graeme James Macfarlane
Published: (2006) -
More Than a Pore: The Cellular Response to Cholesterol-Dependent Cytolysins
by: Sara K. B. Cassidy, et al.
Published: (2013-04-01) -
Modulation of Actin Dynamics by the Cholesterol-Dependent Cytolysin Pneumolysin - a novel mechanism beyond pore formation
by: Hupp, Sabrina
Published: (2012)