Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia
In pregnancy, maternal physiology is subject to considerable adaptations, including alterations in cardiovascular and metabolic function as well as development of immunological tolerance towards the fetus. In an oocyte donation pregnancy, the fetus is fully allogeneic towards the mother, since it ca...
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doaj-0603b939471c44f0b35935cfce17bee62020-11-25T00:05:02ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01205115010.3390/ijms20051150ijms20051150Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-EclampsiaManon Bos0Mirthe H. Schoots1Bernadette O. Fernandez2Monika Mikus-Lelinska3Laurie C. Lau4Michael Eikmans5Harry van Goor6Sanne J. Gordijn7Andreas Pasch8Martin Feelisch9Marie-Louise P. van der Hoorn10Department of Pathology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsClinical & Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton, SO17 1BJ, UKClinical & Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton, SO17 1BJ, UKClinical & Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton, SO17 1BJ, UKDepartment of Immunohematology and Blood transfusion, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Obstetrics, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Biomedical Research, University of Bern, 3012 Bern, SwitzerlandClinical & Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton, SO17 1BJ, UKDepartment of Obstetrics and Gynaecology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsIn pregnancy, maternal physiology is subject to considerable adaptations, including alterations in cardiovascular and metabolic function as well as development of immunological tolerance towards the fetus. In an oocyte donation pregnancy, the fetus is fully allogeneic towards the mother, since it carries both oocyte donor antigens and paternal antigens. Therefore, oocyte donation pregnancies result in an immunologically challenging pregnancy, which is reflected by a higher-than-normal risk to develop pre-eclampsia. Based on the allogeneic conditions in oocyte donation pregnancies, we hypothesized that this situation may translate into alterations in concentration of stable readouts of constituents of the reactive species interactome (RSI) compared to normal pregnancies, especially serum free thiols, nitric oxide (NO) and hydrogen sulfide (H2S) related metabolites. Indeed, total free thiol levels and nitrite (NO2−) concentrations were significantly lower whereas protein-bound NO and sulfate (SO42−) concentrations were significantly higher in both oocyte donation and naturally conceived pregnancies complicated by pre-eclampsia. The increased concentrations of nitrite observed in uncomplicated oocyte donation pregnancies suggest that endothelial NO production is compensatorily enhanced to lower vascular tone. More research is warranted on the role of the RSI and bioenergetic status in uncomplicated oocyte donation pregnancies and oocyte donation pregnancies complicated by pre-eclampsia.http://www.mdpi.com/1422-0067/20/5/1150oocyte donationreactive species interactomethiolsnitric oxidehydrogen sulfidepre-eclampsia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manon Bos Mirthe H. Schoots Bernadette O. Fernandez Monika Mikus-Lelinska Laurie C. Lau Michael Eikmans Harry van Goor Sanne J. Gordijn Andreas Pasch Martin Feelisch Marie-Louise P. van der Hoorn |
spellingShingle |
Manon Bos Mirthe H. Schoots Bernadette O. Fernandez Monika Mikus-Lelinska Laurie C. Lau Michael Eikmans Harry van Goor Sanne J. Gordijn Andreas Pasch Martin Feelisch Marie-Louise P. van der Hoorn Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia International Journal of Molecular Sciences oocyte donation reactive species interactome thiols nitric oxide hydrogen sulfide pre-eclampsia |
author_facet |
Manon Bos Mirthe H. Schoots Bernadette O. Fernandez Monika Mikus-Lelinska Laurie C. Lau Michael Eikmans Harry van Goor Sanne J. Gordijn Andreas Pasch Martin Feelisch Marie-Louise P. van der Hoorn |
author_sort |
Manon Bos |
title |
Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia |
title_short |
Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia |
title_full |
Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia |
title_fullStr |
Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia |
title_full_unstemmed |
Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia |
title_sort |
reactive species interactome alterations in oocyte donation pregnancies in the absence and presence of pre-eclampsia |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-03-01 |
description |
In pregnancy, maternal physiology is subject to considerable adaptations, including alterations in cardiovascular and metabolic function as well as development of immunological tolerance towards the fetus. In an oocyte donation pregnancy, the fetus is fully allogeneic towards the mother, since it carries both oocyte donor antigens and paternal antigens. Therefore, oocyte donation pregnancies result in an immunologically challenging pregnancy, which is reflected by a higher-than-normal risk to develop pre-eclampsia. Based on the allogeneic conditions in oocyte donation pregnancies, we hypothesized that this situation may translate into alterations in concentration of stable readouts of constituents of the reactive species interactome (RSI) compared to normal pregnancies, especially serum free thiols, nitric oxide (NO) and hydrogen sulfide (H2S) related metabolites. Indeed, total free thiol levels and nitrite (NO2−) concentrations were significantly lower whereas protein-bound NO and sulfate (SO42−) concentrations were significantly higher in both oocyte donation and naturally conceived pregnancies complicated by pre-eclampsia. The increased concentrations of nitrite observed in uncomplicated oocyte donation pregnancies suggest that endothelial NO production is compensatorily enhanced to lower vascular tone. More research is warranted on the role of the RSI and bioenergetic status in uncomplicated oocyte donation pregnancies and oocyte donation pregnancies complicated by pre-eclampsia. |
topic |
oocyte donation reactive species interactome thiols nitric oxide hydrogen sulfide pre-eclampsia |
url |
http://www.mdpi.com/1422-0067/20/5/1150 |
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