High Risk Thyroid Nodule Discrimination and Management by Modified TI-RADS

• Main Authors: Li M, Wei L, Li F, Kan Y, Liang X, Zhang H, Liu J
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-01-01
• Series: Cancer Management and Research
• Subjects: thyroid cancer; thyroid nodules; high-risk nodules; thyroid ultrasound; ti-rads report system
• Online Access: https://www.dovepress.com/high-risk-thyroid-nodule-discrimination-and-management-by-modified-ti--peer-reviewed-article-CMAR

Menghui Li,1,2,* Lijuan Wei,1,* Fangxuan Li,1 Yanyan Kan,1 Xiaofeng Liang,1 Huan Zhang,1 Juntian Liu1,2 1Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China; 2National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Menghui Li; Juntian LiuTianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, People’s Republic of ChinaTel/Fax [phone]Email [e-mail] : [e-mail]: Thyroid cancer is the most common primary malignant disorder of the thyroid. We aimed to illustrate the modified TI-RADS report system for differentiating malignant thyroid nodules from benign ones, and especially its role in the management of high risk nodules.Methods: In this retrospective study, 5,162 healthy individuals who underwent thyroid ultrasound according to modified TI-RADS from January 2014 to December 2014 were enrolled and followed up during the whole 5 years, and the medical data were investigated and reviewed.Results: The total detection rate of thyroid nodules was 39.40%. The total detection rate of thyroid cancer was 0.66%. Most thyroid cancers were single-shot, located at unilateral, at early clinical stages, without lymph node metastases, and with low recurrence risk. All patients had thyroid papillary carcinoma, except one thyroid medullary carcinoma. Based on modified TI-RADS classification, at the end of 5 years follow-up, more changes of thyroid nodules grade status were observed in grades 4a and above. The higher the grade status, the more malignant advances were occurred. The modified TI-RADS report system played an instructional role in adding medical treatment choice and decision for clinicians.Conclusion: The modified TI-RADS report system plays an important role in thyroid benign and malignant nodule identification and management.Keywords: thyroid cancer, thyroid nodules, high-risk nodules, thyroid ultrasound, TI-RADS report system