Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture
Abstract Primary hepatocytes cultured in vitro are a powerful tool to study the functions of hepatocytes and to evaluate the metabolism and toxicity of new drugs. However, in vitro culture of hepatocytes has proven to be very difficult. Ordinary culture conditions lead to dedifferentiation of hepato...
Main Authors: | Ren Guo, Xinxiu Xu, Yuting Lu, Xin Xie |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-07-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-06433-3 |
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