Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations
A simple, and rapid spectrophotometric method for the estimation of paracetamol has been developed. The methods is based on diazotisation of 2,4-dichloroaniline followed by a coupling reaction with paracetamol in sodium hydroxide medium. All variables affecting the reaction conditions were carefully...
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College of Science for Women, University of Baghdad
2015-06-01
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Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2072 |
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doaj-060c49a1f9d646a6a512c65a4c6f4cc62020-11-25T00:36:58ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862015-06-0112210.21123/bsj.12.2.317-323Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical PreparationsBaghdad Science JournalA simple, and rapid spectrophotometric method for the estimation of paracetamol has been developed. The methods is based on diazotisation of 2,4-dichloroaniline followed by a coupling reaction with paracetamol in sodium hydroxide medium. All variables affecting the reaction conditions were carefully studied. Beer's law is obeyed in the concentration range of 4-350 ?gml?1 at 490 nm .The method is successfully employed for the determination of paracetamol in pharmaceutical preparations. No interferes observed in the proposed method. Analytical parameters such as accuracy and precision have been established for the method and evaluated statistically to assess the application of the method. http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2072Spectrophotometric determination, Paracetamol, Diazotisation. |
collection |
DOAJ |
language |
Arabic |
format |
Article |
sources |
DOAJ |
author |
Baghdad Science Journal |
spellingShingle |
Baghdad Science Journal Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations Baghdad Science Journal Spectrophotometric determination, Paracetamol, Diazotisation. |
author_facet |
Baghdad Science Journal |
author_sort |
Baghdad Science Journal |
title |
Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations |
title_short |
Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations |
title_full |
Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations |
title_fullStr |
Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations |
title_full_unstemmed |
Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations |
title_sort |
spectrophotometric determination of paracetamol in bulk and pharmaceutical preparations |
publisher |
College of Science for Women, University of Baghdad |
series |
Baghdad Science Journal |
issn |
2078-8665 2411-7986 |
publishDate |
2015-06-01 |
description |
A simple, and rapid spectrophotometric method for the estimation of paracetamol has been developed. The methods is based on diazotisation of 2,4-dichloroaniline followed by a coupling reaction with paracetamol in sodium hydroxide medium. All variables affecting the reaction conditions were carefully studied. Beer's law is obeyed in the concentration range of 4-350 ?gml?1 at 490 nm .The method is successfully employed for the determination of paracetamol in pharmaceutical preparations. No interferes observed in the proposed method. Analytical parameters such as accuracy and precision have been established for the method and evaluated statistically to assess the application of the method. |
topic |
Spectrophotometric determination, Paracetamol, Diazotisation. |
url |
http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2072 |
work_keys_str_mv |
AT baghdadsciencejournal spectrophotometricdeterminationofparacetamolinbulkandpharmaceuticalpreparations |
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