The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illness
Background: The usefulness of laboratory tests in the decision-making process with regard to early identification of dengue virus infection has not been widely reported, particularly the aspartate aminotransferase (AST)/platelet count ratio index during a patient's days of illness. The aim of t...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-07-01
|
Series: | Journal of Infection and Public Health |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S187603412030410X |
id |
doaj-060f2bcd8dbe4630a339ac18d27f9680 |
---|---|
record_format |
Article |
spelling |
doaj-060f2bcd8dbe4630a339ac18d27f96802020-11-25T02:53:20ZengElsevierJournal of Infection and Public Health1876-03412020-07-01137980984The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illnessAnwar E. Ahmed0Bassam Dahman1Asmaa Altamimi2Donna K. McClish3Hamdan AL-Jahdali4Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Department of Preventive Medicine & Biostatistics, Bethesda, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia; Corresponding author at: Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA.Virginia Commonwealth University, Richmond, VA, USATropical Diseases Center, National Health Laboratory, Saudi Center for Disease Prevention and Control (Saudi CDC), Riyadh, Saudi ArabiaVirginia Commonwealth University, Richmond, VA, USAKing Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Ministry of the National Guard – Health Affairs, Riyadh, Saudi ArabiaBackground: The usefulness of laboratory tests in the decision-making process with regard to early identification of dengue virus infection has not been widely reported, particularly the aspartate aminotransferase (AST)/platelet count ratio index during a patient's days of illness. The aim of this study was to examine the pattern of the ratio index over the course of illness and identify whether it is a marker of dengue virus infection in dengue patients, as well as to assess the role of other laboratory tests. Methods: A chart review of 205 dengue patients was analyzed using available records of 845 laboratory results within different time intervals or exam dates during the course of illness. We used repeated measures mixed binary logistic regression analyses to model the dengue virus infection, defined as giving at least one positive antibody test (yes/no). Results: The high risk of dengue virus infection in dengue patients was found in the male gender (adjusted OR = 4.316, 95% CI: 1.285–14.498, P = 0.018), in patients with a high AST/platelet count ratio index (adjusted OR = 1.438, 95% CI: 1.057–1.957, P = 0.021), in patients with a low MCV level (adjusted OR = 0.815, 95% CI: 0.679–0.978, P = 0.028), and in patients with a low ALT level (adjusted OR = 0.996, 95% CI: 0.993–0.999, P = 0.010). Conclusion: Laboratory markers, in particular the AST/platelet count ratio index, can be useful for clinicians to strengthen the decision-making process in primary care settings. Furthermore, our model revealed that low MCV and low ALT are predictors of the dengue virus infection, while being a male increases the risk of dengue virus infection. More studies are needed to evaluate the impact of the AST/platelet count ratio index on the severity of dengue fever infection during the onset of symptoms and course of treatment.http://www.sciencedirect.com/science/article/pii/S187603412030410XAST/platelet ratio indexALTMCVSevere dengue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anwar E. Ahmed Bassam Dahman Asmaa Altamimi Donna K. McClish Hamdan AL-Jahdali |
spellingShingle |
Anwar E. Ahmed Bassam Dahman Asmaa Altamimi Donna K. McClish Hamdan AL-Jahdali The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illness Journal of Infection and Public Health AST/platelet ratio index ALT MCV Severe dengue |
author_facet |
Anwar E. Ahmed Bassam Dahman Asmaa Altamimi Donna K. McClish Hamdan AL-Jahdali |
author_sort |
Anwar E. Ahmed |
title |
The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illness |
title_short |
The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illness |
title_full |
The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illness |
title_fullStr |
The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illness |
title_full_unstemmed |
The aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: Course of illness |
title_sort |
aspartate aminotransferase/platelet count ratio index as a marker of dengue virus infection: course of illness |
publisher |
Elsevier |
series |
Journal of Infection and Public Health |
issn |
1876-0341 |
publishDate |
2020-07-01 |
description |
Background: The usefulness of laboratory tests in the decision-making process with regard to early identification of dengue virus infection has not been widely reported, particularly the aspartate aminotransferase (AST)/platelet count ratio index during a patient's days of illness. The aim of this study was to examine the pattern of the ratio index over the course of illness and identify whether it is a marker of dengue virus infection in dengue patients, as well as to assess the role of other laboratory tests. Methods: A chart review of 205 dengue patients was analyzed using available records of 845 laboratory results within different time intervals or exam dates during the course of illness. We used repeated measures mixed binary logistic regression analyses to model the dengue virus infection, defined as giving at least one positive antibody test (yes/no). Results: The high risk of dengue virus infection in dengue patients was found in the male gender (adjusted OR = 4.316, 95% CI: 1.285–14.498, P = 0.018), in patients with a high AST/platelet count ratio index (adjusted OR = 1.438, 95% CI: 1.057–1.957, P = 0.021), in patients with a low MCV level (adjusted OR = 0.815, 95% CI: 0.679–0.978, P = 0.028), and in patients with a low ALT level (adjusted OR = 0.996, 95% CI: 0.993–0.999, P = 0.010). Conclusion: Laboratory markers, in particular the AST/platelet count ratio index, can be useful for clinicians to strengthen the decision-making process in primary care settings. Furthermore, our model revealed that low MCV and low ALT are predictors of the dengue virus infection, while being a male increases the risk of dengue virus infection. More studies are needed to evaluate the impact of the AST/platelet count ratio index on the severity of dengue fever infection during the onset of symptoms and course of treatment. |
topic |
AST/platelet ratio index ALT MCV Severe dengue |
url |
http://www.sciencedirect.com/science/article/pii/S187603412030410X |
work_keys_str_mv |
AT anwareahmed theaspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT bassamdahman theaspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT asmaaaltamimi theaspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT donnakmcclish theaspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT hamdanaljahdali theaspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT anwareahmed aspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT bassamdahman aspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT asmaaaltamimi aspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT donnakmcclish aspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness AT hamdanaljahdali aspartateaminotransferaseplateletcountratioindexasamarkerofdenguevirusinfectioncourseofillness |
_version_ |
1724725170842632192 |