Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis
Background and Objectives: Osteoprotegerin (OPG), a potent osteoclast activation inhibitor, decreases bone resorption and plays a role in mediating bone mineral density (BMD). Our aim was to evaluate the relationship between BMD and serum OPG in maintenance hemodialysis (MHD) patients. Materials and...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
|
Series: | Medicina |
Subjects: | |
Online Access: | https://www.mdpi.com/1648-9144/57/8/762 |
id |
doaj-060ffbc5a8644757979e8621e9d971f8 |
---|---|
record_format |
Article |
spelling |
doaj-060ffbc5a8644757979e8621e9d971f82021-08-26T14:02:45ZengMDPI AGMedicina1010-660X1648-91442021-07-015776276210.3390/medicina57080762Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance HemodialysisChia-Wen Lu0Chih-Hsien Wang1Bang-Gee Hsu2Jen-Pi Tsai3Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanSchool of Medicine, Tzu Chi University, Hualien 97004, TaiwanBackground and Objectives: Osteoprotegerin (OPG), a potent osteoclast activation inhibitor, decreases bone resorption and plays a role in mediating bone mineral density (BMD). Our aim was to evaluate the relationship between BMD and serum OPG in maintenance hemodialysis (MHD) patients. Materials and Methods: Fasting blood samples were obtained from 75 MHD patients. BMD was measured by dual-energy X-ray absorptiometry in lumbar vertebrae (L2–L4). The WHO classification criteria were applied to define osteopenia and osteoporosis. A commercial enzyme-linked immunosorbent assay was used to measure serum OPG values. Results: Among all MHD patients, seven (9.3%) and 20 patients (26.7%) were defined as osteoporosis and osteopenia, respectively. Female patients had lower lumbar BMD than males (<i>p</i> = 0.002). Older age (<i>p</i> = 0.023), increased serum OPG (<i>p</i> < 0.001) urea reduction rate (<i>p</i> = 0.021), Kt/V (<i>p</i> = 0.027), and decreased body mass index (<i>p</i> = 0.006) and triglycerides (<i>p</i> = 0.020) were significantly different between the normal, osteopenia, and osteoporosis groups. Lumbar spine BMD was positively correlated with body mass index (BMI) (<i>p</i> < 0.001) but negatively correlated with OPG (<i>p</i> < 0.001) and age (<i>p</i> = 0.003). After grouping patients into T scores < −1 and < −2.5, female sex and OPG (adjusted odds ratio [aOR] 1.022, 95% confidence interval [C.I.] 1.011–1.034, <i>p</i> < 0.001) were predictors of T scores < −1, whereas only OPG was predictive of T scores < −2.5 (aOR 1.015, 95% C.I. 1.005–1.026, <i>p</i> = 0.004) by multivariate stepwise logistic regression analysis. The areas under the curve for predicting T scores < −1 or < −2.5 were 0.920 (95% C.I. 0.834–0.970, <i>p</i> < 0.001) and 0.958 (95% C.I. 0.885–0.991, <i>p</i> < 0.001), respectively. Conclusions: Increased serum OPG negatively correlated with lumbar BMD and could be a potential biomarker predictive of osteoporosis in MHD patients.https://www.mdpi.com/1648-9144/57/8/762bone mineral densityhemodialysisosteoprotegerinosteopeniaosteoporosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chia-Wen Lu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai |
spellingShingle |
Chia-Wen Lu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis Medicina bone mineral density hemodialysis osteoprotegerin osteopenia osteoporosis |
author_facet |
Chia-Wen Lu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai |
author_sort |
Chia-Wen Lu |
title |
Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis |
title_short |
Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis |
title_full |
Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis |
title_fullStr |
Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis |
title_full_unstemmed |
Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis |
title_sort |
serum osteoprotegerin level is negatively associated with bone mineral density in patients undergoing maintenance hemodialysis |
publisher |
MDPI AG |
series |
Medicina |
issn |
1010-660X 1648-9144 |
publishDate |
2021-07-01 |
description |
Background and Objectives: Osteoprotegerin (OPG), a potent osteoclast activation inhibitor, decreases bone resorption and plays a role in mediating bone mineral density (BMD). Our aim was to evaluate the relationship between BMD and serum OPG in maintenance hemodialysis (MHD) patients. Materials and Methods: Fasting blood samples were obtained from 75 MHD patients. BMD was measured by dual-energy X-ray absorptiometry in lumbar vertebrae (L2–L4). The WHO classification criteria were applied to define osteopenia and osteoporosis. A commercial enzyme-linked immunosorbent assay was used to measure serum OPG values. Results: Among all MHD patients, seven (9.3%) and 20 patients (26.7%) were defined as osteoporosis and osteopenia, respectively. Female patients had lower lumbar BMD than males (<i>p</i> = 0.002). Older age (<i>p</i> = 0.023), increased serum OPG (<i>p</i> < 0.001) urea reduction rate (<i>p</i> = 0.021), Kt/V (<i>p</i> = 0.027), and decreased body mass index (<i>p</i> = 0.006) and triglycerides (<i>p</i> = 0.020) were significantly different between the normal, osteopenia, and osteoporosis groups. Lumbar spine BMD was positively correlated with body mass index (BMI) (<i>p</i> < 0.001) but negatively correlated with OPG (<i>p</i> < 0.001) and age (<i>p</i> = 0.003). After grouping patients into T scores < −1 and < −2.5, female sex and OPG (adjusted odds ratio [aOR] 1.022, 95% confidence interval [C.I.] 1.011–1.034, <i>p</i> < 0.001) were predictors of T scores < −1, whereas only OPG was predictive of T scores < −2.5 (aOR 1.015, 95% C.I. 1.005–1.026, <i>p</i> = 0.004) by multivariate stepwise logistic regression analysis. The areas under the curve for predicting T scores < −1 or < −2.5 were 0.920 (95% C.I. 0.834–0.970, <i>p</i> < 0.001) and 0.958 (95% C.I. 0.885–0.991, <i>p</i> < 0.001), respectively. Conclusions: Increased serum OPG negatively correlated with lumbar BMD and could be a potential biomarker predictive of osteoporosis in MHD patients. |
topic |
bone mineral density hemodialysis osteoprotegerin osteopenia osteoporosis |
url |
https://www.mdpi.com/1648-9144/57/8/762 |
work_keys_str_mv |
AT chiawenlu serumosteoprotegerinlevelisnegativelyassociatedwithbonemineraldensityinpatientsundergoingmaintenancehemodialysis AT chihhsienwang serumosteoprotegerinlevelisnegativelyassociatedwithbonemineraldensityinpatientsundergoingmaintenancehemodialysis AT banggeehsu serumosteoprotegerinlevelisnegativelyassociatedwithbonemineraldensityinpatientsundergoingmaintenancehemodialysis AT jenpitsai serumosteoprotegerinlevelisnegativelyassociatedwithbonemineraldensityinpatientsundergoingmaintenancehemodialysis |
_version_ |
1721191649427587072 |