Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders

Background: Psychiatric disorders are common mental disorders without a pathological biomarker. Classic genetic studies found that an extra X chromosome frequently causes psychiatric symptoms in patients with either Klinefelter syndrome (XXY) or Triple X syndrome (XXX). Over-dosage of some X-linked...

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Bibliographic Details
Main Authors: Baohu Ji, Kerin K. Higa, John R. Kelsoe, Xianjin Zhou
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300426