Astrocyte HIV-1 Tat Differentially Modulates Behavior and Brain MMP/TIMP Balance During Short and Prolonged Induction in Transgenic Mice

Astrocyte HIV-1 Tat Differentially Modulates Behavior and Brain MMP/TIMP Balance During Short and Prolonged Induction in Transgenic Mice

Despite effective antiretroviral therapy (ART), mild forms of HIV-associated neurocognitive disorders (HAND) continue to afflict approximately half of all people living with HIV (PLWH). As PLWH age, HIV-associated inflammation perturbs the balance between brain matrix metalloproteinases (MMPs) and t...

Full description

Bibliographic Details
Main Authors: Chaitanya R. Joshi, Satomi Stacy, Nathalie Sumien, Anuja Ghorpade, Kathleen Borgmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neurology
Subjects:
HIV-associated neurocognitive disorders (HAND)
neuroinflammation
TIMP1
iTat mice
anxiety
locomotor activity
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.593188/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2020.593188/full

Similar Items