Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders.
Little is known about disorder-specific biomarkers of bipolar disorder (BD) and major depressive disorder (MDD). Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs) of individu...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5193412?pdf=render |
id |
doaj-06156b4132f24e78b3a4771ee6082c07 |
---|---|
record_format |
Article |
spelling |
doaj-06156b4132f24e78b3a4771ee6082c072020-11-24T20:50:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016849310.1371/journal.pone.0168493Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders.Toshio MatsubaraKoji MatsuoKenichiro HaradaMasayuki NakanoMami NakashimaToshio WatanukiKazuteru EgashiraMatakazu FurukawaNaofumi MatsunagaYoshifumi WatanabeLittle is known about disorder-specific biomarkers of bipolar disorder (BD) and major depressive disorder (MDD). Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs) of individuals with BD), MDD group (17 patients with MDD, 17 FDRs of individuals with MDD), and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test (TMT), respectively. The BD group showed a significant main effect of diagnosis in the gray matter (GM) volume of the anterior cingulate cortex (ACC; p = 0.01) and left insula (p < 0.01). FDRs of individuals with BD showed significantly smaller left ACC GM volume than healthy subjects (p < 0.01), and patients with BD showed significantly smaller ACC (p < 0.01) and left insular GM volume (p < 0.01) than healthy subjects. The MDD group showed a tendency toward a main effect of diagnosis in the right and left insular GM volume. The BD group showed a significantly inverse correlation between the left insular GM volume and TMT-A scores (p < 0.05). Our results suggest that the ACC volume could be a distinct endophenotype of BD, while the insular volume could be a shared BD and MDD endophenotype. Moreover, the insula could be associated with cognitive decline and poor outcome in BD.http://europepmc.org/articles/PMC5193412?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Toshio Matsubara Koji Matsuo Kenichiro Harada Masayuki Nakano Mami Nakashima Toshio Watanuki Kazuteru Egashira Matakazu Furukawa Naofumi Matsunaga Yoshifumi Watanabe |
spellingShingle |
Toshio Matsubara Koji Matsuo Kenichiro Harada Masayuki Nakano Mami Nakashima Toshio Watanuki Kazuteru Egashira Matakazu Furukawa Naofumi Matsunaga Yoshifumi Watanabe Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders. PLoS ONE |
author_facet |
Toshio Matsubara Koji Matsuo Kenichiro Harada Masayuki Nakano Mami Nakashima Toshio Watanuki Kazuteru Egashira Matakazu Furukawa Naofumi Matsunaga Yoshifumi Watanabe |
author_sort |
Toshio Matsubara |
title |
Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders. |
title_short |
Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders. |
title_full |
Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders. |
title_fullStr |
Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders. |
title_full_unstemmed |
Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders. |
title_sort |
distinct and shared endophenotypes of neural substrates in bipolar and major depressive disorders. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Little is known about disorder-specific biomarkers of bipolar disorder (BD) and major depressive disorder (MDD). Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs) of individuals with BD), MDD group (17 patients with MDD, 17 FDRs of individuals with MDD), and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test (TMT), respectively. The BD group showed a significant main effect of diagnosis in the gray matter (GM) volume of the anterior cingulate cortex (ACC; p = 0.01) and left insula (p < 0.01). FDRs of individuals with BD showed significantly smaller left ACC GM volume than healthy subjects (p < 0.01), and patients with BD showed significantly smaller ACC (p < 0.01) and left insular GM volume (p < 0.01) than healthy subjects. The MDD group showed a tendency toward a main effect of diagnosis in the right and left insular GM volume. The BD group showed a significantly inverse correlation between the left insular GM volume and TMT-A scores (p < 0.05). Our results suggest that the ACC volume could be a distinct endophenotype of BD, while the insular volume could be a shared BD and MDD endophenotype. Moreover, the insula could be associated with cognitive decline and poor outcome in BD. |
url |
http://europepmc.org/articles/PMC5193412?pdf=render |
work_keys_str_mv |
AT toshiomatsubara distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT kojimatsuo distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT kenichiroharada distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT masayukinakano distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT maminakashima distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT toshiowatanuki distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT kazuteruegashira distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT matakazufurukawa distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT naofumimatsunaga distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders AT yoshifumiwatanabe distinctandsharedendophenotypesofneuralsubstratesinbipolarandmajordepressivedisorders |
_version_ |
1716804967711375360 |