Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh
Purpose The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. Methods PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implan...
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Korean Continence Society
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doaj-0623076e8312480a852912d27c90ebee2020-11-24T23:48:02ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312017-04-0121Suppl 1S485410.5213/inj.1734882.441663Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable MeshSang-Don Yoon0Young-Sam Kwon1Kyu-Sung Lee2 Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Korea Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, KoreaPurpose The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. Methods PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated. Results The weight and tensile strength of the PLLA prosthesis was stable for 180 days. In addition, the surface of the PLLA mesh was not digested under in vitro or in vivo conditions as determined by scanning electron microscope. Histologically, there were no significant changes in the diameters of implanted PLLA mesh and subtype fibers over the course of 180 days. Likewise, there were no significant changes in the number of inflammatory and mast cells after 180 days, nor was there an increase in the percentage of collagen surrounding the PLLA mesh. Conclusions The results indicate that PLLA prostheses have good rigidity and biocompatibility in vivo and in vitro.http://www.einj.org/upload/pdf/inj-1734882-441.pdfBiodegradationBiocompatibilityPolylevolactic acidMesh |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sang-Don Yoon Young-Sam Kwon Kyu-Sung Lee |
spellingShingle |
Sang-Don Yoon Young-Sam Kwon Kyu-Sung Lee Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh International Neurourology Journal Biodegradation Biocompatibility Polylevolactic acid Mesh |
author_facet |
Sang-Don Yoon Young-Sam Kwon Kyu-Sung Lee |
author_sort |
Sang-Don Yoon |
title |
Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh |
title_short |
Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh |
title_full |
Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh |
title_fullStr |
Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh |
title_full_unstemmed |
Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh |
title_sort |
biodegradation and biocompatibility of poly l-lactic acid implantable mesh |
publisher |
Korean Continence Society |
series |
International Neurourology Journal |
issn |
2093-4777 2093-6931 |
publishDate |
2017-04-01 |
description |
Purpose The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. Methods PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated. Results The weight and tensile strength of the PLLA prosthesis was stable for 180 days. In addition, the surface of the PLLA mesh was not digested under in vitro or in vivo conditions as determined by scanning electron microscope. Histologically, there were no significant changes in the diameters of implanted PLLA mesh and subtype fibers over the course of 180 days. Likewise, there were no significant changes in the number of inflammatory and mast cells after 180 days, nor was there an increase in the percentage of collagen surrounding the PLLA mesh. Conclusions The results indicate that PLLA prostheses have good rigidity and biocompatibility in vivo and in vitro. |
topic |
Biodegradation Biocompatibility Polylevolactic acid Mesh |
url |
http://www.einj.org/upload/pdf/inj-1734882-441.pdf |
work_keys_str_mv |
AT sangdonyoon biodegradationandbiocompatibilityofpolyllacticacidimplantablemesh AT youngsamkwon biodegradationandbiocompatibilityofpolyllacticacidimplantablemesh AT kyusunglee biodegradationandbiocompatibilityofpolyllacticacidimplantablemesh |
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