Upregulation of NETO2 gene in colorectal cancer
Abstract Background Neuropilin and tolloid-like 2 (NETO2) is a single-pass transmembrane protein that has been shown primarily implicated in neuron-specific processes. Upregulation of NETO2 gene was also detected in several cancer types. In colorectal cancer (CRC), it was associated with tumor progr...
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doaj-062cdf590797482caa78f67f73cb03c82020-11-25T03:38:41ZengBMCBMC Genetics1471-21562017-12-0118S1455210.1186/s12863-017-0581-8Upregulation of NETO2 gene in colorectal cancerMaria S. Fedorova0Anastasiya V. Snezhkina1Elena A. Pudova2Ivan S. Abramov3Anastasiya V. Lipatova4Sergey L. Kharitonov5Asiya F. Sadritdinova6Kirill M. Nyushko7Kseniya M. Klimina8Mikhail M. Belyakov9Elena N. Slavnova10Nataliya V. Melnikova11Maria A. Chernichenko12Dmitry V. Sidorov13Marina V. Kiseleva14Andrey D. Kaprin15Boris Y. Alekseev16Alexey A. Dmitriev17Anna V. Kudryavtseva18Engelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesNational Medical Research Radiological Center, Ministry of Health of the Russian FederationVavilov Institute of General Genetics, Russian Academy of SciencesNational Medical Research Radiological Center, Ministry of Health of the Russian FederationNational Medical Research Radiological Center, Ministry of Health of the Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of SciencesNational Medical Research Radiological Center, Ministry of Health of the Russian FederationNational Medical Research Radiological Center, Ministry of Health of the Russian FederationNational Medical Research Radiological Center, Ministry of Health of the Russian FederationNational Medical Research Radiological Center, Ministry of Health of the Russian FederationNational Medical Research Radiological Center, Ministry of Health of the Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesAbstract Background Neuropilin and tolloid-like 2 (NETO2) is a single-pass transmembrane protein that has been shown primarily implicated in neuron-specific processes. Upregulation of NETO2 gene was also detected in several cancer types. In colorectal cancer (CRC), it was associated with tumor progression, invasion, and metastasis, and seems to be involved in epithelial-mesenchymal transition (EMT). However, the mechanism of NETO2 action is still poorly understood. Results We have revealed significant increase in the expression of NETO2 gene and deregulation of eight EMT-related genes in CRC. Four of them were upregulated (TWIST1, SNAIL1, LEF1, and FOXA2); the mRNA levels of other genes (FOXA1, BMP2, BMP5, and SMAD7) were decreased. Expression of NETO2 gene was weakly correlated with that of genes involved in the EMT process. Conclusions We found considerable NETO2 upregulation, but no significant correlation between the expression of NETO2 and EMT-related genes in CRC. Thus, NETO2 may be involved in CRC progression, but is not directly associated with EMT.http://link.springer.com/article/10.1186/s12863-017-0581-8Colorectal cancerNETO2Epithelial-mesenchymal transitionGene expressionQPCR |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria S. Fedorova Anastasiya V. Snezhkina Elena A. Pudova Ivan S. Abramov Anastasiya V. Lipatova Sergey L. Kharitonov Asiya F. Sadritdinova Kirill M. Nyushko Kseniya M. Klimina Mikhail M. Belyakov Elena N. Slavnova Nataliya V. Melnikova Maria A. Chernichenko Dmitry V. Sidorov Marina V. Kiseleva Andrey D. Kaprin Boris Y. Alekseev Alexey A. Dmitriev Anna V. Kudryavtseva |
spellingShingle |
Maria S. Fedorova Anastasiya V. Snezhkina Elena A. Pudova Ivan S. Abramov Anastasiya V. Lipatova Sergey L. Kharitonov Asiya F. Sadritdinova Kirill M. Nyushko Kseniya M. Klimina Mikhail M. Belyakov Elena N. Slavnova Nataliya V. Melnikova Maria A. Chernichenko Dmitry V. Sidorov Marina V. Kiseleva Andrey D. Kaprin Boris Y. Alekseev Alexey A. Dmitriev Anna V. Kudryavtseva Upregulation of NETO2 gene in colorectal cancer BMC Genetics Colorectal cancer NETO2 Epithelial-mesenchymal transition Gene expression QPCR |
author_facet |
Maria S. Fedorova Anastasiya V. Snezhkina Elena A. Pudova Ivan S. Abramov Anastasiya V. Lipatova Sergey L. Kharitonov Asiya F. Sadritdinova Kirill M. Nyushko Kseniya M. Klimina Mikhail M. Belyakov Elena N. Slavnova Nataliya V. Melnikova Maria A. Chernichenko Dmitry V. Sidorov Marina V. Kiseleva Andrey D. Kaprin Boris Y. Alekseev Alexey A. Dmitriev Anna V. Kudryavtseva |
author_sort |
Maria S. Fedorova |
title |
Upregulation of NETO2 gene in colorectal cancer |
title_short |
Upregulation of NETO2 gene in colorectal cancer |
title_full |
Upregulation of NETO2 gene in colorectal cancer |
title_fullStr |
Upregulation of NETO2 gene in colorectal cancer |
title_full_unstemmed |
Upregulation of NETO2 gene in colorectal cancer |
title_sort |
upregulation of neto2 gene in colorectal cancer |
publisher |
BMC |
series |
BMC Genetics |
issn |
1471-2156 |
publishDate |
2017-12-01 |
description |
Abstract Background Neuropilin and tolloid-like 2 (NETO2) is a single-pass transmembrane protein that has been shown primarily implicated in neuron-specific processes. Upregulation of NETO2 gene was also detected in several cancer types. In colorectal cancer (CRC), it was associated with tumor progression, invasion, and metastasis, and seems to be involved in epithelial-mesenchymal transition (EMT). However, the mechanism of NETO2 action is still poorly understood. Results We have revealed significant increase in the expression of NETO2 gene and deregulation of eight EMT-related genes in CRC. Four of them were upregulated (TWIST1, SNAIL1, LEF1, and FOXA2); the mRNA levels of other genes (FOXA1, BMP2, BMP5, and SMAD7) were decreased. Expression of NETO2 gene was weakly correlated with that of genes involved in the EMT process. Conclusions We found considerable NETO2 upregulation, but no significant correlation between the expression of NETO2 and EMT-related genes in CRC. Thus, NETO2 may be involved in CRC progression, but is not directly associated with EMT. |
topic |
Colorectal cancer NETO2 Epithelial-mesenchymal transition Gene expression QPCR |
url |
http://link.springer.com/article/10.1186/s12863-017-0581-8 |
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