Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration

Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration

The retinal pigment epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD. Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD, but the biology underlying disease-associated var...

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Bibliographic Details
Main Authors: Li Xuan Tan, Colin J. Germer, Nilsa La Cunza, Aparna Lakkaraju
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Retinal pigment epithelium
Complement
Mitochondria
Cholesterol
Ceramide
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309861

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http://www.sciencedirect.com/science/article/pii/S2213231720309861

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