Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation

Long noncoding RNAs have a wide range of physiological functions, though their role in viral infection and latency is poorly understood. Here the authors show a lncRNA NRON can induce degradation of HIV-1 protein Tat, potentially contributing to latent infection.

Bibliographic Details
Main Authors:	Jun Li, Cancan Chen, Xiancai Ma, Guannan Geng, Bingfeng Liu, Yijun Zhang, Shaoyang Zhang, Fudi Zhong, Chao Liu, Yue Yin, Weiping Cai, Hui Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11730

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spelling	doaj-0658e7370fef4de8af787a5e70268d4a2021-05-11T11:05:49ZengNature Publishing GroupNature Communications2041-17232016-06-017111010.1038/ncomms11730Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradationJun Li0Cancan Chen1Xiancai Ma2Guannan Geng3Bingfeng Liu4Yijun Zhang5Shaoyang Zhang6Fudi Zhong7Chao Liu8Yue Yin9Weiping Cai10Hui Zhang11Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityDepartment of Infectious Diseases, Guangzhou 8th People’s HospitalInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen UniversityLong noncoding RNAs have a wide range of physiological functions, though their role in viral infection and latency is poorly understood. Here the authors show a lncRNA NRON can induce degradation of HIV-1 protein Tat, potentially contributing to latent infection.https://doi.org/10.1038/ncomms11730
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jun Li Cancan Chen Xiancai Ma Guannan Geng Bingfeng Liu Yijun Zhang Shaoyang Zhang Fudi Zhong Chao Liu Yue Yin Weiping Cai Hui Zhang
spellingShingle	Jun Li Cancan Chen Xiancai Ma Guannan Geng Bingfeng Liu Yijun Zhang Shaoyang Zhang Fudi Zhong Chao Liu Yue Yin Weiping Cai Hui Zhang Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation Nature Communications
author_facet	Jun Li Cancan Chen Xiancai Ma Guannan Geng Bingfeng Liu Yijun Zhang Shaoyang Zhang Fudi Zhong Chao Liu Yue Yin Weiping Cai Hui Zhang
author_sort	Jun Li
title	Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
title_short	Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
title_full	Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
title_fullStr	Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
title_full_unstemmed	Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
title_sort	long noncoding rna nron contributes to hiv-1 latency by specifically inducing tat protein degradation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-06-01
description	Long noncoding RNAs have a wide range of physiological functions, though their role in viral infection and latency is poorly understood. Here the authors show a lncRNA NRON can induce degradation of HIV-1 protein Tat, potentially contributing to latent infection.
url	https://doi.org/10.1038/ncomms11730
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Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation

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