Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis B
ObjectiveTo investigate the effect of pegylated interferon α-2a (PEG-IFN α-2a) combined with thymosin α1 (Tα1) on the quality of life (QOL) in patients with chronic hepatitis B (CHB). MethodsA total of 148 patients with CHB who were admitted to our department from October 2008 to October 2012 were s...
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Editorial Department of Journal of Clinical Hepatology
2013-12-01
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doaj-065faf13364149a2b5b6ec94497cfe372020-11-24T22:55:08ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562013-12-01291292292510.3969/j.issn.1001-5256.2013.12.012Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis BLU Jianguo0Department of Infectious Diseases, The First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi 545002, ChinaObjectiveTo investigate the effect of pegylated interferon α-2a (PEG-IFN α-2a) combined with thymosin α1 (Tα1) on the quality of life (QOL) in patients with chronic hepatitis B (CHB). MethodsA total of 148 patients with CHB who were admitted to our department from October 2008 to October 2012 were selected and randomly divided into observation group (n=74) and control group (n=74). The control group was treated with PEG-IFN α-2a, while the observation group was treated with PEG-IFN α-2a plus Tα1. The hepatitis B virus (HBV) DNA load, QOL, Chronic Liver Disease Questionnaire scores, and adverse reactions were compared between the two groups at months 3, 6, and 12 of treatment. Comparisons between groups were made by independent-samples t test; comparisons between variables before and after treatment were made by paired t test; categorical data were analyzed by chi-square test. ResultsCompared with the control group, the observation group had significantly higher decrease in HBV DNA load and virological response rate at months 3 (t=2.281, P=0.02; χ2=3.950, P=0.04), 6 (t=3.237, P=0.00;χ2=4.022, P=0.04), and 12 (t=3.197, P=0.00; χ2=4.028, P=0.04), significantly higher overall QOL, physiological, social relation, fatigue, and anxiety scores at month 6 (t=2.039-3.472, P<0.05), and significantly higher overall QOL, general health status, physiological, psychological, social relation, fatigue, systemic symptom, activity, anxiety, and environment scores at month 12 (t=2.020-3.201, P<0.05). ConclusionPEG-IFN α-2a combined with Tα1 can improve immunity and antiviral ability and promote HBV clearance in the treatment of CHB, thus leading to the improvement in patients’ QOL. This therapy holds promise for clinical application.http://www.lcgdbzz.org/qk_content.asp?id=5564&ClassID=111152919interferon alpha -2a; thymosin; hepatitis Bchronic; quality of life |
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DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
LU Jianguo |
spellingShingle |
LU Jianguo Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis B Linchuang Gandanbing Zazhi interferon alpha -2a; thymosin; hepatitis B chronic; quality of life |
author_facet |
LU Jianguo |
author_sort |
LU Jianguo |
title |
Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis B |
title_short |
Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis B |
title_full |
Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis B |
title_fullStr |
Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis B |
title_full_unstemmed |
Effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis B |
title_sort |
effect of pegylated interferon α-2a combined with thymosin α1 on quality of life in patients with chronic hepatitis b |
publisher |
Editorial Department of Journal of Clinical Hepatology |
series |
Linchuang Gandanbing Zazhi |
issn |
1001-5256 1001-5256 |
publishDate |
2013-12-01 |
description |
ObjectiveTo investigate the effect of pegylated interferon α-2a (PEG-IFN α-2a) combined with thymosin α1 (Tα1) on the quality of life (QOL) in patients with chronic hepatitis B (CHB). MethodsA total of 148 patients with CHB who were admitted to our department from October 2008 to October 2012 were selected and randomly divided into observation group (n=74) and control group (n=74). The control group was treated with PEG-IFN α-2a, while the observation group was treated with PEG-IFN α-2a plus Tα1. The hepatitis B virus (HBV) DNA load, QOL, Chronic Liver Disease Questionnaire scores, and adverse reactions were compared between the two groups at months 3, 6, and 12 of treatment. Comparisons between groups were made by independent-samples t test; comparisons between variables before and after treatment were made by paired t test; categorical data were analyzed by chi-square test. ResultsCompared with the control group, the observation group had significantly higher decrease in HBV DNA load and virological response rate at months 3 (t=2.281, P=0.02; χ2=3.950, P=0.04), 6 (t=3.237, P=0.00;χ2=4.022, P=0.04), and 12 (t=3.197, P=0.00; χ2=4.028, P=0.04), significantly higher overall QOL, physiological, social relation, fatigue, and anxiety scores at month 6 (t=2.039-3.472, P<0.05), and significantly higher overall QOL, general health status, physiological, psychological, social relation, fatigue, systemic symptom, activity, anxiety, and environment scores at month 12 (t=2.020-3.201, P<0.05). ConclusionPEG-IFN α-2a combined with Tα1 can improve immunity and antiviral ability and promote HBV clearance in the treatment of CHB, thus leading to the improvement in patients’ QOL. This therapy holds promise for clinical application. |
topic |
interferon alpha -2a; thymosin; hepatitis B chronic; quality of life |
url |
http://www.lcgdbzz.org/qk_content.asp?id=5564&ClassID=111152919 |
work_keys_str_mv |
AT lujianguo effectofpegylatedinterferona2acombinedwiththymosina1onqualityoflifeinpatientswithchronichepatitisb |
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