Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up
Background To evaluate mid-term oncological and functional outcomes in patients with prostate cancer treated by robot-assisted laparoscopic radical prostatectomy (RALP) at our institution. Methods We retrospectively reviewed the medical records of 128 patients with prostate cancer who underwent RALP...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Yeungnam University College of Medicine
2018-12-01
|
Series: | Yeungnam University Journal of Medicine |
Subjects: | |
Online Access: | http://yujm.yu.ac.kr/upload/pdf/yujm-2018-35-2-171.pdf |
id |
doaj-0666e7b26d33409ab6986d58b668e6ab |
---|---|
record_format |
Article |
spelling |
doaj-0666e7b26d33409ab6986d58b668e6ab2020-11-25T00:31:14ZengYeungnam University College of MedicineYeungnam University Journal of Medicine2384-02932018-12-0135217117810.12701/yujm.2018.35.2.1712407Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-upJun-Koo Kang0Jae-Wook Chung1So Young Chun2Yun-Sok Ha3Seock Hwan Choi4Jun Nyung Lee5Bum Soo Kim6Ghil Suk Yoon7Hyun Tae Kim8Tae-Hwan Kim9Tae Gyun Kwon10 Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea Department of Urology, Kyungpook National University School of Medicine, Daegu, KoreaBackground To evaluate mid-term oncological and functional outcomes in patients with prostate cancer treated by robot-assisted laparoscopic radical prostatectomy (RALP) at our institution. Methods We retrospectively reviewed the medical records of 128 patients with prostate cancer who underwent RALP at our institution between February 2008 and April 2010. All patients enrolled in this study were followed up for at least 5 years. We analyzed biochemical recurrence (BCR)-free survival using a Kaplan-Meier survival curve analysis and predictive factors for BCR using multivariate Cox regression analysis. Continence recovery rate, defined as no use of urinary pads, was also evaluated. Results Based on the D’Amico risk classification, there were 30 low-risk patients (23.4%), 47 intermediate-risk patients (38.8%), and 51 high-risk patients (39.8%), preoperatively. Based on pathological findings, 50.0% of patients (64/128) showed non-organ confined disease (≥T3a) and 26.6% (34/128) had high grade disease (Gleason score ≥8). During a median follow-up period of 71 months (range, 66-78 months), the frequency of BCR was 33.6% (43/128) and the median BCR-free survival was 65.9 (0.4-88.0) months. Multivariate Cox regression analysis revealed that high grade disease (Gleason score ≥8) was an independent predictor for BCR (hazard ratio=4.180, 95% confidence interval=1.02-17.12, p=0.047). In addition, a majority of patients remained continent following the RALP procedure, without the need for additional intervention for post-prostatectomy incontinence. Conclusion Our study demonstrated acceptable outcomes following an initial RALP procedure, despite 50% of the patients investigated demonstrating high-risk features associated with non-organ confined disease.http://yujm.yu.ac.kr/upload/pdf/yujm-2018-35-2-171.pdfBCRProstate cancerProstatectomyUrinary incontinence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun-Koo Kang Jae-Wook Chung So Young Chun Yun-Sok Ha Seock Hwan Choi Jun Nyung Lee Bum Soo Kim Ghil Suk Yoon Hyun Tae Kim Tae-Hwan Kim Tae Gyun Kwon |
spellingShingle |
Jun-Koo Kang Jae-Wook Chung So Young Chun Yun-Sok Ha Seock Hwan Choi Jun Nyung Lee Bum Soo Kim Ghil Suk Yoon Hyun Tae Kim Tae-Hwan Kim Tae Gyun Kwon Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up Yeungnam University Journal of Medicine BCR Prostate cancer Prostatectomy Urinary incontinence |
author_facet |
Jun-Koo Kang Jae-Wook Chung So Young Chun Yun-Sok Ha Seock Hwan Choi Jun Nyung Lee Bum Soo Kim Ghil Suk Yoon Hyun Tae Kim Tae-Hwan Kim Tae Gyun Kwon |
author_sort |
Jun-Koo Kang |
title |
Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up |
title_short |
Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up |
title_full |
Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up |
title_fullStr |
Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up |
title_full_unstemmed |
Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up |
title_sort |
oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up |
publisher |
Yeungnam University College of Medicine |
series |
Yeungnam University Journal of Medicine |
issn |
2384-0293 |
publishDate |
2018-12-01 |
description |
Background To evaluate mid-term oncological and functional outcomes in patients with prostate cancer treated by robot-assisted laparoscopic radical prostatectomy (RALP) at our institution. Methods We retrospectively reviewed the medical records of 128 patients with prostate cancer who underwent RALP at our institution between February 2008 and April 2010. All patients enrolled in this study were followed up for at least 5 years. We analyzed biochemical recurrence (BCR)-free survival using a Kaplan-Meier survival curve analysis and predictive factors for BCR using multivariate Cox regression analysis. Continence recovery rate, defined as no use of urinary pads, was also evaluated. Results Based on the D’Amico risk classification, there were 30 low-risk patients (23.4%), 47 intermediate-risk patients (38.8%), and 51 high-risk patients (39.8%), preoperatively. Based on pathological findings, 50.0% of patients (64/128) showed non-organ confined disease (≥T3a) and 26.6% (34/128) had high grade disease (Gleason score ≥8). During a median follow-up period of 71 months (range, 66-78 months), the frequency of BCR was 33.6% (43/128) and the median BCR-free survival was 65.9 (0.4-88.0) months. Multivariate Cox regression analysis revealed that high grade disease (Gleason score ≥8) was an independent predictor for BCR (hazard ratio=4.180, 95% confidence interval=1.02-17.12, p=0.047). In addition, a majority of patients remained continent following the RALP procedure, without the need for additional intervention for post-prostatectomy incontinence. Conclusion Our study demonstrated acceptable outcomes following an initial RALP procedure, despite 50% of the patients investigated demonstrating high-risk features associated with non-organ confined disease. |
topic |
BCR Prostate cancer Prostatectomy Urinary incontinence |
url |
http://yujm.yu.ac.kr/upload/pdf/yujm-2018-35-2-171.pdf |
work_keys_str_mv |
AT junkookang oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT jaewookchung oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT soyoungchun oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT yunsokha oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT seockhwanchoi oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT junnyunglee oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT bumsookim oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT ghilsukyoon oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT hyuntaekim oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT taehwankim oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup AT taegyunkwon oncologicalandfunctionaloutcomesfollowingrobotassistedlaparoscopicradicalprostatectomyatasingleinstitutionaminimum5yearfollowup |
_version_ |
1725322926103724032 |