A microwave-catalyzed rapid, efficient and ecofriendly synthesis of substituted pyrazol-5-ones

A microwave-catalyzed rapid, efficient and ecofriendly synthesis of substituted pyrazol-5-ones

A series of 1-(3,4-dihydro-3-oxo-2H-1,4-benzoxazine-2-carbonyl)-3-methyl-4-(substituted phenylhydrazono)-2-pyrazolin-5-ones have been synthesized by the reaction of 2H-3,4-dihydro-3-oxo-1,4-benzoxazine-2-carboxylic acid hydrazide with substituted acetoacetic ester derivatives using acetic acid as so...

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Bibliographic Details
Main Authors: RAHUL P. GAVANDE, VIJAY V. DABHOLKAR
Format: Article
Language:English
Published: Serbian Chemical Society 2003-10-01
Series:Journal of the Serbian Chemical Society
Subjects:
o-amino phenol
1
4-benzoxazine
hydrazine hydrate
3
4-substituted pyrazol-5-one
Online Access:http://www.shd.org.yu/HtDocs/SHD/Vol68/No10/V68-No10-05.pdf
Description
Summary:A series of 1-(3,4-dihydro-3-oxo-2H-1,4-benzoxazine-2-carbonyl)-3-methyl-4-(substituted phenylhydrazono)-2-pyrazolin-5-ones have been synthesized by the reaction of 2H-3,4-dihydro-3-oxo-1,4-benzoxazine-2-carboxylic acid hydrazide with substituted acetoacetic ester derivatives using acetic acid as solvent under microwave irradiation (MWI), as well as by conventional methods. The reaction rate is enhanced tremendously and the yields are improved under MWI as compared to conventional methods.
ISSN:0352-5139

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