Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response
PCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15 % of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are...
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doaj-0669689a6d3445d3815825ebedb226ea2021-01-01T00:06:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012238438410.3390/ijms22010384Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive ResponsePedro-Antonio Regidor0Anna Mueller1Manuela Sailer2Fernando Gonzalez Santos3Jose Miguel Rizo4Fernando Moreno Egea5Exeltis Europe, Adalperostr. 84, 85737 Ismaning, GermanyExeltis Germany GmbH, Adalperostr. 84, 85737 Ismaning, GermanyExeltis Germany GmbH, Adalperostr. 84, 85737 Ismaning, GermanySolutex SA. Avenida de la Transición Española 24, 28108 Alcobendas, SpainChemo OTC. Calle Manuel Pombo Angulo 28, 28050 Madrid, SpainSolutex SA. Avenida de la Transición Española 24, 28108 Alcobendas, SpainPCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15 % of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are often associated with the disease. Furthermore, PCOS represents a status of chronic inflammation with permanently elevated levels of inflammatory markers including IL-6 and IL-18, TNF-α, and CRP. Inflammation, as discovered only recently, consists of two processes occurring concomitantly: active initiation, involving “classical” mediators including prostaglandins and leukotrienes, and active resolution processes based on the action of so-called specialized pro-resolving mediators (SPMs). These novel lipid mediator molecules derive from the essential ω3-poly-unsaturated fatty acids (PUFAs) DHA and EPA and are synthesized via specific intermediates. The role and benefits of SPMs in chronic inflammatory diseases like obesity, atherosclerosis, and Diabetes mellitus has become a subject of intense research during the last years and since PCOS features several of these pathologies, this review aims at summarizing potential roles of SPMs in this disease and their putative use as novel therapeutics.https://www.mdpi.com/1422-0067/22/1/384PCOSobesityinflammationspecialized pro-resolving mediators (SPMs) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pedro-Antonio Regidor Anna Mueller Manuela Sailer Fernando Gonzalez Santos Jose Miguel Rizo Fernando Moreno Egea |
spellingShingle |
Pedro-Antonio Regidor Anna Mueller Manuela Sailer Fernando Gonzalez Santos Jose Miguel Rizo Fernando Moreno Egea Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response International Journal of Molecular Sciences PCOS obesity inflammation specialized pro-resolving mediators (SPMs) |
author_facet |
Pedro-Antonio Regidor Anna Mueller Manuela Sailer Fernando Gonzalez Santos Jose Miguel Rizo Fernando Moreno Egea |
author_sort |
Pedro-Antonio Regidor |
title |
Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response |
title_short |
Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response |
title_full |
Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response |
title_fullStr |
Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response |
title_full_unstemmed |
Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response |
title_sort |
chronic inflammation in pcos: the potential benefits of specialized pro-resolving lipid mediators (spms) in the improvement of the resolutive response |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-12-01 |
description |
PCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15 % of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are often associated with the disease. Furthermore, PCOS represents a status of chronic inflammation with permanently elevated levels of inflammatory markers including IL-6 and IL-18, TNF-α, and CRP. Inflammation, as discovered only recently, consists of two processes occurring concomitantly: active initiation, involving “classical” mediators including prostaglandins and leukotrienes, and active resolution processes based on the action of so-called specialized pro-resolving mediators (SPMs). These novel lipid mediator molecules derive from the essential ω3-poly-unsaturated fatty acids (PUFAs) DHA and EPA and are synthesized via specific intermediates. The role and benefits of SPMs in chronic inflammatory diseases like obesity, atherosclerosis, and Diabetes mellitus has become a subject of intense research during the last years and since PCOS features several of these pathologies, this review aims at summarizing potential roles of SPMs in this disease and their putative use as novel therapeutics. |
topic |
PCOS obesity inflammation specialized pro-resolving mediators (SPMs) |
url |
https://www.mdpi.com/1422-0067/22/1/384 |
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