Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response

PCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15 % of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are...

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Main Authors: Pedro-Antonio Regidor, Anna Mueller, Manuela Sailer, Fernando Gonzalez Santos, Jose Miguel Rizo, Fernando Moreno Egea
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/1/384
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spelling doaj-0669689a6d3445d3815825ebedb226ea2021-01-01T00:06:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012238438410.3390/ijms22010384Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive ResponsePedro-Antonio Regidor0Anna Mueller1Manuela Sailer2Fernando Gonzalez Santos3Jose Miguel Rizo4Fernando Moreno Egea5Exeltis Europe, Adalperostr. 84, 85737 Ismaning, GermanyExeltis Germany GmbH, Adalperostr. 84, 85737 Ismaning, GermanyExeltis Germany GmbH, Adalperostr. 84, 85737 Ismaning, GermanySolutex SA. Avenida de la Transición Española 24, 28108 Alcobendas, SpainChemo OTC. Calle Manuel Pombo Angulo 28, 28050 Madrid, SpainSolutex SA. Avenida de la Transición Española 24, 28108 Alcobendas, SpainPCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15 % of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are often associated with the disease. Furthermore, PCOS represents a status of chronic inflammation with permanently elevated levels of inflammatory markers including IL-6 and IL-18, TNF-α, and CRP. Inflammation, as discovered only recently, consists of two processes occurring concomitantly: active initiation, involving “classical” mediators including prostaglandins and leukotrienes, and active resolution processes based on the action of so-called specialized pro-resolving mediators (SPMs). These novel lipid mediator molecules derive from the essential ω3-poly-unsaturated fatty acids (PUFAs) DHA and EPA and are synthesized via specific intermediates. The role and benefits of SPMs in chronic inflammatory diseases like obesity, atherosclerosis, and Diabetes mellitus has become a subject of intense research during the last years and since PCOS features several of these pathologies, this review aims at summarizing potential roles of SPMs in this disease and their putative use as novel therapeutics.https://www.mdpi.com/1422-0067/22/1/384PCOSobesityinflammationspecialized pro-resolving mediators (SPMs)
collection DOAJ
language English
format Article
sources DOAJ
author Pedro-Antonio Regidor
Anna Mueller
Manuela Sailer
Fernando Gonzalez Santos
Jose Miguel Rizo
Fernando Moreno Egea
spellingShingle Pedro-Antonio Regidor
Anna Mueller
Manuela Sailer
Fernando Gonzalez Santos
Jose Miguel Rizo
Fernando Moreno Egea
Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response
International Journal of Molecular Sciences
PCOS
obesity
inflammation
specialized pro-resolving mediators (SPMs)
author_facet Pedro-Antonio Regidor
Anna Mueller
Manuela Sailer
Fernando Gonzalez Santos
Jose Miguel Rizo
Fernando Moreno Egea
author_sort Pedro-Antonio Regidor
title Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response
title_short Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response
title_full Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response
title_fullStr Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response
title_full_unstemmed Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response
title_sort chronic inflammation in pcos: the potential benefits of specialized pro-resolving lipid mediators (spms) in the improvement of the resolutive response
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-12-01
description PCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15 % of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are often associated with the disease. Furthermore, PCOS represents a status of chronic inflammation with permanently elevated levels of inflammatory markers including IL-6 and IL-18, TNF-α, and CRP. Inflammation, as discovered only recently, consists of two processes occurring concomitantly: active initiation, involving “classical” mediators including prostaglandins and leukotrienes, and active resolution processes based on the action of so-called specialized pro-resolving mediators (SPMs). These novel lipid mediator molecules derive from the essential ω3-poly-unsaturated fatty acids (PUFAs) DHA and EPA and are synthesized via specific intermediates. The role and benefits of SPMs in chronic inflammatory diseases like obesity, atherosclerosis, and Diabetes mellitus has become a subject of intense research during the last years and since PCOS features several of these pathologies, this review aims at summarizing potential roles of SPMs in this disease and their putative use as novel therapeutics.
topic PCOS
obesity
inflammation
specialized pro-resolving mediators (SPMs)
url https://www.mdpi.com/1422-0067/22/1/384
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