Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary Aldosteronism
Aldosterone-producing adenoma (APA) is a main cause of primary aldosteronism (PA). Given that a large benign-appearing unilateral masse (>1 cm in diameter) may represent an aldosterone and cortisol-co-secreting adenoma, dexamethasone suppression testing is required in such patients to exclude...
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doaj-0686382c62704a02bcf21c677418747c2020-11-25T03:26:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-09-011110.3389/fendo.2020.00593563931Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary AldosteronismHongman Wang0Ying Song1Zhixin Xu2Ying Jing3Wenwen He4Zhengping Feng5Qifu Li6Shumin Yang7Department of Endocrinology, Chongqing General Hospital, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaAldosterone-producing adenoma (APA) is a main cause of primary aldosteronism (PA). Given that a large benign-appearing unilateral masse (>1 cm in diameter) may represent an aldosterone and cortisol-co-secreting adenoma, dexamethasone suppression testing is required in such patients to exclude or confirm the diagnosis of hypercortisolism. Tuberculosis is highly prevalent in China, and rifamycins are often used in these patients. Rifapentine belongs to the rifamycin family, and we herein for the first time report a case of misdiagnosis of hypercortisolism due to rifapentine use in a patient with APA. Thus, in patients treated with rifapentine, diagnosis of hypercortisolism based on dexamethasone suppression tests can be very misleading.https://www.frontiersin.org/article/10.3389/fendo.2020.00593/fulldexamethasone suppression testsprimary aldosteronismrifapentinehypercortisolismhypertension |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongman Wang Ying Song Zhixin Xu Ying Jing Wenwen He Zhengping Feng Qifu Li Shumin Yang |
spellingShingle |
Hongman Wang Ying Song Zhixin Xu Ying Jing Wenwen He Zhengping Feng Qifu Li Shumin Yang Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary Aldosteronism Frontiers in Endocrinology dexamethasone suppression tests primary aldosteronism rifapentine hypercortisolism hypertension |
author_facet |
Hongman Wang Ying Song Zhixin Xu Ying Jing Wenwen He Zhengping Feng Qifu Li Shumin Yang |
author_sort |
Hongman Wang |
title |
Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary Aldosteronism |
title_short |
Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary Aldosteronism |
title_full |
Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary Aldosteronism |
title_fullStr |
Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary Aldosteronism |
title_full_unstemmed |
Abnormal Dexamethasone Suppression Tests in a Rifapentine-Treated Patient With Primary Aldosteronism |
title_sort |
abnormal dexamethasone suppression tests in a rifapentine-treated patient with primary aldosteronism |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2020-09-01 |
description |
Aldosterone-producing adenoma (APA) is a main cause of primary aldosteronism (PA). Given that a large benign-appearing unilateral masse (>1 cm in diameter) may represent an aldosterone and cortisol-co-secreting adenoma, dexamethasone suppression testing is required in such patients to exclude or confirm the diagnosis of hypercortisolism. Tuberculosis is highly prevalent in China, and rifamycins are often used in these patients. Rifapentine belongs to the rifamycin family, and we herein for the first time report a case of misdiagnosis of hypercortisolism due to rifapentine use in a patient with APA. Thus, in patients treated with rifapentine, diagnosis of hypercortisolism based on dexamethasone suppression tests can be very misleading. |
topic |
dexamethasone suppression tests primary aldosteronism rifapentine hypercortisolism hypertension |
url |
https://www.frontiersin.org/article/10.3389/fendo.2020.00593/full |
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