Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24514-w |
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doaj-068df09610874565a1ef7f05fbef6c89 |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Qi Zhang Bin Ju Jiwan Ge Jasper Fuk-Woo Chan Lin Cheng Ruoke Wang Weijin Huang Mengqi Fang Peng Chen Bing Zhou Shuo Song Sisi Shan Baohua Yan Senyan Zhang Xiangyang Ge Jiazhen Yu Juanjuan Zhao Haiyan Wang Li Liu Qining Lv Lili Fu Xuanling Shi Kwok Yung Yuen Lei Liu Youchun Wang Zhiwei Chen Linqi Zhang Xinquan Wang Zheng Zhang |
| spellingShingle |
Qi Zhang Bin Ju Jiwan Ge Jasper Fuk-Woo Chan Lin Cheng Ruoke Wang Weijin Huang Mengqi Fang Peng Chen Bing Zhou Shuo Song Sisi Shan Baohua Yan Senyan Zhang Xiangyang Ge Jiazhen Yu Juanjuan Zhao Haiyan Wang Li Liu Qining Lv Lili Fu Xuanling Shi Kwok Yung Yuen Lei Liu Youchun Wang Zhiwei Chen Linqi Zhang Xinquan Wang Zheng Zhang Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2 Nature Communications |
| author_facet |
Qi Zhang Bin Ju Jiwan Ge Jasper Fuk-Woo Chan Lin Cheng Ruoke Wang Weijin Huang Mengqi Fang Peng Chen Bing Zhou Shuo Song Sisi Shan Baohua Yan Senyan Zhang Xiangyang Ge Jiazhen Yu Juanjuan Zhao Haiyan Wang Li Liu Qining Lv Lili Fu Xuanling Shi Kwok Yung Yuen Lei Liu Youchun Wang Zhiwei Chen Linqi Zhang Xinquan Wang Zheng Zhang |
| author_sort |
Qi Zhang |
| title |
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2 |
| title_short |
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2 |
| title_full |
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2 |
| title_fullStr |
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2 |
| title_full_unstemmed |
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2 |
| title_sort |
potent and protective ighv3-53/3-66 public antibodies and their shared escape mutant on the spike of sars-cov-2 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-07-01 |
| description |
Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing the emergence of mutations at position 417 of the Spike protein that confer resistance. |
| url |
https://doi.org/10.1038/s41467-021-24514-w |
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doaj-068df09610874565a1ef7f05fbef6c892021-07-11T11:42:38ZengNature Publishing GroupNature Communications2041-17232021-07-0112111210.1038/s41467-021-24514-wPotent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2Qi Zhang0Bin Ju1Jiwan Ge2Jasper Fuk-Woo Chan3Lin Cheng4Ruoke Wang5Weijin Huang6Mengqi Fang7Peng Chen8Bing Zhou9Shuo Song10Sisi Shan11Baohua Yan12Senyan Zhang13Xiangyang Ge14Jiazhen Yu15Juanjuan Zhao16Haiyan Wang17Li Liu18Qining Lv19Lili Fu20Xuanling Shi21Kwok Yung Yuen22Lei Liu23Youchun Wang24Zhiwei Chen25Linqi Zhang26Xinquan Wang27Zheng Zhang28NexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyThe Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua UniversityState Key Laboratory of Emerging Infectious Diseases, The University of Hong KongInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityDivision of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug ControlNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityThe Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua UniversityThe Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua UniversityInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityState Key Laboratory of Emerging Infectious Diseases, The University of Hong KongInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyDivision of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug ControlState Key Laboratory of Emerging Infectious Diseases, The University of Hong KongNexVac Research Center, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua UniversityThe Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua UniversityInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and TechnologyHere, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing the emergence of mutations at position 417 of the Spike protein that confer resistance.https://doi.org/10.1038/s41467-021-24514-w |